ID   REXO3_SCHPO             Reviewed;         540 AA.
AC   Q9P7H2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=rex3; ORFNames=SPAC1782.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB76270.1; -; Genomic_DNA.
DR   PIR; T50098; T50098.
DR   RefSeq; NP_594715.1; NM_001020142.1.
DR   AlphaFoldDB; Q9P7H2; -.
DR   SMR; Q9P7H2; -.
DR   BioGRID; 278641; 34.
DR   STRING; 4896.SPAC1782.08c.1; -.
DR   iPTMnet; Q9P7H2; -.
DR   MaxQB; Q9P7H2; -.
DR   PaxDb; Q9P7H2; -.
DR   PRIDE; Q9P7H2; -.
DR   EnsemblFungi; SPAC1782.08c.1; SPAC1782.08c.1:pep; SPAC1782.08c.
DR   GeneID; 2542165; -.
DR   KEGG; spo:SPAC1782.08c; -.
DR   PomBase; SPAC1782.08c; rex3.
DR   VEuPathDB; FungiDB:SPAC1782.08c; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   HOGENOM; CLU_022453_5_4_1; -.
DR   InParanoid; Q9P7H2; -.
DR   OMA; LNARYYK; -.
DR   PhylomeDB; Q9P7H2; -.
DR   PRO; PR:Q9P7H2; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; ISO:PomBase.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISO:PomBase.
DR   GO; GO:0034476; P:U5 snRNA 3'-end processing; ISO:PomBase.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000571; Znf_CCCH.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Metal-binding; Nuclease; Nucleus;
KW   Reference proteome; rRNA processing; Zinc; Zinc-finger.
FT   CHAIN           1..540
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120935"
FT   DOMAIN          382..529
FT                   /note="Exonuclease"
FT   ZN_FING         7..34
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ   SEQUENCE   540 AA;  61199 MW;  176CF40457E9AE42 CRC64;
     MFSPLGQFKH IVCPFLRTGR KCQSRNCFFS HDFQNSTKIS PPYSENVEGY PKVKIEKSLP
     YKYDNCKLSI CVPIVTTCIP YHSVENLNFN IRQNISTTLN LEKTNDSIKE TKNENFRMDV
     LETYKCKQLN HQTTHLPTNT VLKKRSLFND AISIVPNKKK QLVSAISTNS DSQGASSNII
     PTPKYDSNSP AGHELRKRMT HLLYESYKDL GYSNAESSML ALLDEKNICE TANSKMIYSS
     SCKSKILSLK KAPKKNEIQG STPDEKLESL VHSEEELILW GYNIGDVAPV NPPDELRECD
     RCGTRFADPR GPCTYHWGKL FREKQGGEKI RTYTCCGVKE GDSSGCIIED NHVFKYRHLP
     YLASVHPFSY LPDSTNSKQL SHCALDCELC YTTNGMELAR LTVVAKESII MDVFIKPKGK
     ILSLNTRFSG IHDAKELESG ITMDQMYIKI KELGMNKNTI LIGHGLENDL NAMRLIHKRV
     IDTALLFTHA RGPPFRYSLK YLTKKYLGTT IQTSTHDSEE DAVSALQLVF YKTKSNESQN