ID   REXO3_YARLI             Reviewed;         757 AA.
AC   Q6CFE7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=RNA exonuclease 3;
DE            EC=3.1.-.-;
GN   Name=REX3; OrderedLocusNames=YALI0B07689g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: 3' to 5' exoribonuclease required for proper 3' end
CC       maturation of MRP RNA and of the U5L snRNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG82848.1; -; Genomic_DNA.
DR   RefSeq; XP_500615.1; XM_500615.1.
DR   AlphaFoldDB; Q6CFE7; -.
DR   SMR; Q6CFE7; -.
DR   STRING; 4952.CAG82848; -.
DR   PRIDE; Q6CFE7; -.
DR   EnsemblFungi; CAG82848; CAG82848; YALI0_B07689g.
DR   GeneID; 2906951; -.
DR   KEGG; yli:YALI0B07689g; -.
DR   VEuPathDB; FungiDB:YALI0_B07689g; -.
DR   HOGENOM; CLU_368108_0_0_1; -.
DR   InParanoid; Q6CFE7; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..757
FT                   /note="RNA exonuclease 3"
FT                   /id="PRO_0000120936"
FT   DOMAIN          597..751
FT                   /note="Exonuclease"
FT   REGION          56..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..521
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..581
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  82343 MW;  E45A571121CC9E53 CRC64;
     MQFSGEGLFF HSPFNSPKKH MFSSSKGLFR GHPCPSIAAG QFCRLLCCPF DHPERVKRES
     ENGSDSAEMV KRRKLEVGQG VARVAGDSSG GKLELPGARQ ALNQRDRPEI EGVGASPKTE
     GGRAEGAEKK EFASSQSSQK EQQETPHASA TPQASVSPQT SAPPQHVSSS VSEDVLKQGK
     NGITSKSEKS SVKQPGSRDI YQPSSSREPP VSSIDTRTSS SPKSALEAVM TTSASPSQSR
     DGSRNTSASP SSSRDAEHLM PTTIFPCPAT VPQRIAYLKA IHSALTDKRK LKFPKRAAIL
     EELAAAKRSA GNYMVYTNEC RVLVKSIKDG SWRGGKAGGT KTDSKTSGHI TSSISNQLDM
     LASKTKPLLA QNGYPVNPDP LKSGLPSNIG IQHCDRCDKA FDVPKVDNYG SCKYHWARAR
     MGGNSTMPEK FYPCCNQPVG MSEGCEEAPR HVYKLHDLND LAFVIPFRTV STSESLDTST
     STSTSTSATT SAPSAKSTKT ASRPASTPTK SLTSSLDLEK SRQPFNKARR PRTIFNGPAV
     NQREPDITLE TMKRGIGESR GQADSQERSS EPRERSARVR EQPSGSCDQA GSLQTSVVAV
     DCEMLYTSLG MELCRVTCID YHGKKTLDRV VRPTGRILDY NTRFSGISDI NEPIITESGE
     KGDSISFEEA HRLILKLINK QTILVGHGLE NDLIAMRLIH DRIIDTSILY PDFNPRYKTA
     LKTLALKYLK RTIQTGEHDS MEDALAALDV VKCHLKG