ID   REXO4_ASHGO             Reviewed;         285 AA.
AC   Q757I9;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=REX4; OrderedLocusNames=AER024W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC       in the processing of ITS1, the internal transcribed spacer localized
CC       between the 18S and 5.8S rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52708.1; -; Genomic_DNA.
DR   RefSeq; NP_984884.1; NM_210238.1.
DR   AlphaFoldDB; Q757I9; -.
DR   SMR; Q757I9; -.
DR   STRING; 33169.AAS52708; -.
DR   EnsemblFungi; AAS52708; AAS52708; AGOS_AER024W.
DR   GeneID; 4621086; -.
DR   KEGG; ago:AGOS_AER024W; -.
DR   eggNOG; KOG2249; Eukaryota.
DR   HOGENOM; CLU_022453_2_0_1; -.
DR   InParanoid; Q757I9; -.
DR   OMA; TMLIYKS; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..285
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131690"
FT   DOMAIN          113..265
FT                   /note="Exonuclease"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  31683 MW;  7BA809FA8324EA51 CRC64;
     MVLSSNWSKL SKTQEKRVKK AEHGKSDGKS DGKTAGVGSR ASGTPPETAQ RRKSKAKTSK
     IMEMVAKMNR EMANSRQNSA EKNEVQKGAL EEKISVDMAQ SGKAGKVGSV GKFVAMDCEF
     VGVGPDGKES VLARVSVVNY YGQEVLDLYV RPKEKVTDWR TWVSGITPAH MKQAVTLEEA
     QRRVAAMLKN RVLIGHGLHH DLEMLMVSHP KAQIRDTSMH GPFREKYGAG KTPSLKKLAR
     EVLNIDIQGK EHSSVEDARA ALLLYKSDKV EFERLHQQRF SRRKA