ID   REXO4_CANAL             Reviewed;         285 AA.
AC   Q5A3Q0; A0A1D8PFD2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=REX4; OrderedLocusNames=CAALFM_C112440WA;
GN   ORFNames=CaO19.12687, CaO19.5220;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC       in the processing of ITS1, the internal transcribed spacer localized
CC       between the 18S and 5.8S rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26861.1; -; Genomic_DNA.
DR   RefSeq; XP_716289.1; XM_711196.2.
DR   AlphaFoldDB; Q5A3Q0; -.
DR   SMR; Q5A3Q0; -.
DR   STRING; 237561.Q5A3Q0; -.
DR   GeneID; 3642012; -.
DR   KEGG; cal:CAALFM_C112440WA; -.
DR   CGD; CAL0000191259; orf19.12687.
DR   VEuPathDB; FungiDB:C1_12440W_A; -.
DR   eggNOG; KOG2249; Eukaryota.
DR   HOGENOM; CLU_022453_2_1_1; -.
DR   InParanoid; Q5A3Q0; -.
DR   OMA; HFLKIDI; -.
DR   OrthoDB; 1562214at2759; -.
DR   PRO; PR:Q5A3Q0; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..285
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131692"
FT   DOMAIN          116..267
FT                   /note="Exonuclease"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  32210 MW;  B861D7C31107CD6F CRC64;
     MAKLSQNWKK LSSKIQDKPK NGSVKKPTLK GKISKKVKAS ISEKLSTTNN TTTTTTTTTS
     TTDVVPIASS TKPTATPLEY TLWTQNHTIN VSHIPKTPKP LPLSRNDSRK LDPGKYVAID
     CEFVGIGKDG EESALARISI INYYGVVLLD TYVRPQERVT DWRTWVSGIQ SYHMQDAIDF
     KTAQLKTMEL INNKILVGHA VNNDLDILFL SHPKSMIRDT CKFPKFREIA GGKSPSLKKL
     IKHFIQVDIQ IGQHSSVEDA RATMLLFRLF KREIEQSMRN RNKRQ