ID   REXO4_CRYNJ             Reviewed;         408 AA.
AC   P0CQ44; Q55WJ1; Q5KJQ4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=REX4; OrderedLocusNames=CNC05710;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC       in the processing of ITS1, the internal transcribed spacer localized
CC       between the 18S and 5.8S rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW42722.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AE017343; AAW42722.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_570029.1; XM_570029.1.
DR   AlphaFoldDB; P0CQ44; -.
DR   SMR; P0CQ44; -.
DR   STRING; 5207.AAW42722; -.
DR   PaxDb; P0CQ44; -.
DR   eggNOG; KOG2249; Eukaryota.
DR   InParanoid; P0CQ44; -.
DR   OrthoDB; 1562214at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..408
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131694"
FT   DOMAIN          131..292
FT                   /note="Exonuclease"
FT   REGION          27..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..340
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..388
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  44977 MW;  DC53E54C4C3E5624 CRC64;
     MDKKKAPGQT VASSNWLQLQ STLSTITKEK DVSNSKAHNS RSSQSPSSSL RSSSRIQRKS
     KHSQGVGQYM GRVEVASTAK TTVSQLRKGK VISNEPCILL EAFSDSPLLH ELRHMVLGNH
     LLSESQKEPG QYLAIDCEMV GVGPNGMENT LARVSIVNYH GAVILDTFVQ PREPVTDYRT
     WISGVKQSDL LGAPQFDEVN KQVANLLHDK ILIGHAIDND LKVLMLTHPG PLTRDTQKYK
     PLQEIAKNKR PGLKKLSELL LGVQIQTGAH SSVVDARVAM ALYRLHKKEW ERSVWRQTEA
     YRSISSVNKP EHVLGKRGHD EKEAEDGEET AGESKRKNRK KSGNGGGRQQ FPGGGRKGIS
     SGLDVIVRRN GQRVDENGRG DGTSRRKAGR GEISTFTGGE SWWEQPAA