ID   REXO4_DEBHA             Reviewed;         272 AA.
AC   Q6BIK6;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=REX4; OrderedLocusNames=DEHA2G09636g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC       in the processing of ITS1, the internal transcribed spacer localized
CC       between the 18S and 5.8S rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90433.2; -; Genomic_DNA.
DR   RefSeq; XP_461965.2; XM_461965.1.
DR   AlphaFoldDB; Q6BIK6; -.
DR   SMR; Q6BIK6; -.
DR   STRING; 4959.XP_461965.2; -.
DR   EnsemblFungi; CAG90433; CAG90433; DEHA2G09636g.
DR   GeneID; 2904855; -.
DR   KEGG; dha:DEHA2G09636g; -.
DR   VEuPathDB; FungiDB:DEHA2G09636g; -.
DR   eggNOG; KOG2249; Eukaryota.
DR   HOGENOM; CLU_022453_2_0_1; -.
DR   InParanoid; Q6BIK6; -.
DR   OMA; HFLKIDI; -.
DR   OrthoDB; 1562214at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..272
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131695"
FT   DOMAIN          99..250
FT                   /note="Exonuclease"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   272 AA;  30722 MW;  696B3A63CAD18994 CRC64;
     MTTTLSSNWK KLSSKLNQGS KVTKQPVKGK NGKTKIKKAE LENTLNITPT LQKSTLSPIE
     LALWTKENDI NVSDIAVQTE KITLIPQGND IRKKEPGKYL AMDCEFVGVG PEGTESALAR
     VSIVNFYGHT VFDKFVKPRE RVTDWRTWVS GVTPKHMNEA ISFQEAQNET SKLLEGRILV
     GHAIHHDLDA LFLSHPKSRI RDTSQYKPFR SISMGKTPSL KKLSSHFLKI DIQGSAHSSV
     EDARATMLLF RLHRKEFEQS IRTQNRKPEK TS