ID   REXO4_DICDI             Reviewed;         298 AA.
AC   Q54U94;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=rexo4; ORFNames=DDB_G0281327;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; AAFI02000040; EAL66960.1; -; Genomic_DNA.
DR   RefSeq; XP_640882.1; XM_635790.1.
DR   AlphaFoldDB; Q54U94; -.
DR   SMR; Q54U94; -.
DR   STRING; 44689.DDB0305008; -.
DR   PaxDb; Q54U94; -.
DR   EnsemblProtists; EAL66960; EAL66960; DDB_G0281327.
DR   GeneID; 8622938; -.
DR   KEGG; ddi:DDB_G0281327; -.
DR   dictyBase; DDB_G0281327; rexo4.
DR   eggNOG; KOG2249; Eukaryota.
DR   HOGENOM; CLU_935163_0_0_1; -.
DR   InParanoid; Q54U94; -.
DR   OMA; YKPLCKL; -.
DR   PhylomeDB; Q54U94; -.
DR   PRO; PR:Q54U94; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..298
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000330893"
FT   DOMAIN          125..275
FT                   /note="Exonuclease"
FT   COILED          1..73
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   298 AA;  34786 MW;  8D1F75EB533F2360 CRC64;
     MRKTVRKNKQ VKRELALLEK EKEEIESFTK VSKTVENKQS INSNWNVTKE KIKNKNNAYQ
     KKKEAKLKLK SATPYTSTKV IEEKKPHIKD FNQLCQEHNI ISPIDDNLVS PTQKEIDNLN
     ESSKFFSIDC KIIEIEGNKG TLGKVCIANQ NGQIIYEKIV KPMDKIVDFR TKFTGLTRDK
     VQREGTDFLQ VQKEVEKILR HKILVGHDLV HDLKNLKLAH KKKLLRDATQ FTKFFNPDTN
     SEDSLKSIAK RELNFSPDNW DPNGKRDTII NVILYKQNQK EWEAFINNKF YGQPIDKN