REXO4_MOUSE
ID REXO4_MOUSE Reviewed; 432 AA.
AC Q6PAQ4; Q3UU17; Q8C524;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=RNA exonuclease 4;
DE EC=3.1.-.-;
DE AltName: Full=Exonuclease XPMC2;
DE AltName: Full=Prevents mitotic catastrophe 2 protein homolog;
GN Name=Rexo4; Synonyms=Gm111, Pmc2, Xpmc2h;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350.
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-432.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as an exonuclease.
CC -!- SUBUNIT: Can bind ESR1 and ESR2. This interaction is abrogated by
CC estrogen and augmented by tamoxifen treatment (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH60147.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AK079733; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAE23812.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK079733; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK138894; BAE23812.1; ALT_INIT; mRNA.
DR EMBL; BC060147; AAH60147.1; ALT_INIT; mRNA.
DR CCDS; CCDS15819.1; -.
DR RefSeq; NP_997117.2; NM_207234.2.
DR AlphaFoldDB; Q6PAQ4; -.
DR SMR; Q6PAQ4; -.
DR BioGRID; 230657; 1.
DR STRING; 10090.ENSMUSP00000109653; -.
DR iPTMnet; Q6PAQ4; -.
DR PhosphoSitePlus; Q6PAQ4; -.
DR EPD; Q6PAQ4; -.
DR jPOST; Q6PAQ4; -.
DR MaxQB; Q6PAQ4; -.
DR PaxDb; Q6PAQ4; -.
DR PeptideAtlas; Q6PAQ4; -.
DR PRIDE; Q6PAQ4; -.
DR ProteomicsDB; 255009; -.
DR Antibodypedia; 18377; 133 antibodies from 25 providers.
DR DNASU; 227656; -.
DR Ensembl; ENSMUST00000114020; ENSMUSP00000109653; ENSMUSG00000052406.
DR GeneID; 227656; -.
DR KEGG; mmu:227656; -.
DR UCSC; uc008iwn.1; mouse.
DR CTD; 57109; -.
DR MGI; MGI:2684957; Rexo4.
DR VEuPathDB; HostDB:ENSMUSG00000052406; -.
DR eggNOG; KOG2249; Eukaryota.
DR GeneTree; ENSGT00940000159607; -.
DR InParanoid; Q6PAQ4; -.
DR OMA; CVYDKYI; -.
DR OrthoDB; 1562214at2759; -.
DR PhylomeDB; Q6PAQ4; -.
DR TreeFam; TF313504; -.
DR BioGRID-ORCS; 227656; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Rexo4; mouse.
DR PRO; PR:Q6PAQ4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6PAQ4; protein.
DR Bgee; ENSMUSG00000052406; Expressed in paneth cell and 251 other tissues.
DR ExpressionAtlas; Q6PAQ4; baseline and differential.
DR Genevisible; Q6PAQ4; MM.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008408; F:3'-5' exonuclease activity; ISO:MGI.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0004519; F:endonuclease activity; ISO:MGI.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; ISO:MGI.
DR GO; GO:0000737; P:DNA catabolic process, endonucleolytic; ISO:MGI.
DR GO; GO:0000738; P:DNA catabolic process, exonucleolytic; ISO:MGI.
DR GO; GO:0006281; P:DNA repair; ISO:MGI.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd06144; REX4_like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR034920; Rex4.
DR InterPro; IPR037431; REX4_DEDDh_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR12801:SF130; PTHR12801:SF130; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 2: Evidence at transcript level;
KW Exonuclease; Hydrolase; Isopeptide bond; Nuclease; Nucleus; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..432
FT /note="RNA exonuclease 4"
FT /id="PRO_0000131704"
FT DOMAIN 230..381
FT /note="Exonuclease"
FT REGION 42..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9GZR2"
FT CROSSLNK 127
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9GZR2"
SQ SEQUENCE 432 AA; 47599 MW; AFEFA9DFCFB4819B CRC64;
MCACAVAGVA VSSLVVPTAE SGEMKTKATA PVPQPGPIRK LARKKAKKKF RKSKALAGSG
VPGSHPAAVA GRPPKAPENF SQNWKALQEL LKQKSQAAEK PLVSQMDDKM HPQIIQQNRK
KASDKSKGDK QRTEKAKSTR GSVTSAPTDR KILVPPTDTS GTEQKKGAKK RTYSDISSHQ
GALKPKWKAT EAAVILNQPT PTEEDIWFDD VDPDDIEDAI GPEAAMLVRK RLGQKKRTIS
LEKEQAFGGL TKALALDCEM VGVGPKGEES IAARVSIVNQ YGKCVYDKYV KPTEPVTDYR
TAVSGIRPEN LKQGEEFEVV KKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKF
KPFRSRVKSG RPSLKRLSEK ILGIRVQQAE HCSIQDAQAA MRLYVMVKRE WESSTANRRA
PAATPQHRIK NS
