ID   REXO4_USTMA             Reviewed;         375 AA.
AC   Q4PER6; A0A0D1E7N9;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=REX4; ORFNames=UMAG_01397;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC       in the processing of ITS1, the internal transcribed spacer localized
CC       between the 18S and 5.8S rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; CM003141; KIS71501.1; -; Genomic_DNA.
DR   RefSeq; XP_011387279.1; XM_011388977.1.
DR   AlphaFoldDB; Q4PER6; -.
DR   SMR; Q4PER6; -.
DR   STRING; 5270.UM01397P0; -.
DR   EnsemblFungi; KIS71501; KIS71501; UMAG_01397.
DR   GeneID; 23562435; -.
DR   KEGG; uma:UMAG_01397; -.
DR   VEuPathDB; FungiDB:UMAG_01397; -.
DR   eggNOG; KOG2249; Eukaryota.
DR   HOGENOM; CLU_022453_6_1_1; -.
DR   InParanoid; Q4PER6; -.
DR   OMA; WFAEDIS; -.
DR   OrthoDB; 1562214at2759; -.
DR   Proteomes; UP000000561; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..375
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131700"
FT   DOMAIN          134..297
FT                   /note="Exonuclease"
FT   REGION          21..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  40396 MW;  FDB449276237EC2D CRC64;
     MKSAASSSSS SAGSNWKALK KTLGSDASSS SASSSTNNRR KLSTSESTKP KRTRLDAKEK
     DAEGSKSCSP APTSLPWFAE DISPQDLELV RESASGKMAR SGEWEGIVDA KLKKQIILGG
     LPSDASSAKK EPGNYLAIDC EMVGVGDKGS ESILARVSIV NFHGATIYDQ FVRPQEKVTD
     YRTWVSGVRP KDLKGAPSFS QVQGEVANLI KGKVLVGHAI QNDLKALLLS HPKVLIRDTA
     TFQPLRDLAK TKYPSLKKLA KLVLGIDIQL EGESHSSVED ARATMAVFRS QKPKWDEMLR
     SQNKGGRGSL ARLASRSSAA NKVWKAPANG QAVDAASPAL DKRSMLAFTS ASAVHDTVRL
     KPRMAAKADW WKESM