ID   REXO4_XENLA             Reviewed;         421 AA.
AC   Q91560; Q7ZY64;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
DE   AltName: Full=Exonuclease XPMC2;
DE   AltName: Full=Prevents mitotic catastrophe 2 protein;
GN   Name=rexo4; Synonyms=xpmc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC   TISSUE=Ovary;
RX   PubMed=7854324; DOI=10.1007/bf00288613;
RA   Su J.-Y., Maller J.L.;
RT   "Cloning and expression of a Xenopus gene that prevents mitotic catastrophe
RT   in fission yeast.";
RL   Mol. Gen. Genet. 246:387-396(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:7854324}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; U10185; AAA82179.1; -; mRNA.
DR   EMBL; BC043958; AAH43958.1; -; mRNA.
DR   PIR; S53818; S53818.
DR   RefSeq; NP_001079510.1; NM_001086041.1.
DR   AlphaFoldDB; Q91560; -.
DR   SMR; Q91560; -.
DR   DNASU; 379197; -.
DR   GeneID; 379197; -.
DR   KEGG; xla:379197; -.
DR   CTD; 379197; -.
DR   Xenbase; XB-GENE-6251614; rexo4.S.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 379197; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034920; Rex4.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR12801:SF130; PTHR12801:SF130; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..421
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131705"
FT   DOMAIN          234..385
FT                   /note="Exonuclease"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        8
FT                   /note="K -> M (in Ref. 1; AAA82179)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  46697 MW;  FC4F6333228C7E9E CRC64;
     MAKAKVKKDQ SPCSGSLGKT ANTPKQKRKQ KQRKFWQNHP KITTKTGETK KVSLLLPPKG
     PQEFSSNWKA LQELLKPKEN QALPATTLAK CPKKDQKVSE KKTEESVPQK SGHKINGGIT
     SVSAIAKGAK APSQATPTKA AEKSDEVSKG KKRKIMAEAT DTEHQGKKPQ GEAQPQPPKV
     DIWFDDVDPD DIEAALGPEA GRVAREMQGI TDTRSPTVDK ILVKERAFEG LTRTVAMDCE
     MVGVGMDGEE SILARVSIVN LFGKCVYDKY VKPTERVTDY RTAVSGIRPE DVKKGEPFKV
     VQKEVSEILR GRTLVGHAVH NDLKILFLDH PKKAIRDTQK YKPFKQKVKS GRPSLKLLCE
     KILNVKVQTG EHCSVQDAQA AMRLYTMEKK SWEVAIKAKY TGVMPVDRKS KGPQKDKQCP
     Q