ID   REXO4_XENTR             Reviewed;         414 AA.
AC   Q6DEW6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
DE   AltName: Full=Exonuclease XPMC2;
DE   AltName: Full=Prevents mitotic catastrophe 2 protein;
GN   Name=rexo4; Synonyms=xpmc2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; BC076977; AAH76977.1; -; mRNA.
DR   RefSeq; NP_001006868.1; NM_001006867.1.
DR   AlphaFoldDB; Q6DEW6; -.
DR   SMR; Q6DEW6; -.
DR   STRING; 8364.ENSXETP00000049947; -.
DR   PaxDb; Q6DEW6; -.
DR   DNASU; 448635; -.
DR   Ensembl; ENSXETT00000049947; ENSXETP00000049947; ENSXETG00000023096.
DR   GeneID; 448635; -.
DR   CTD; 57109; -.
DR   Xenbase; XB-GENE-6258946; rexo4.
DR   eggNOG; KOG2249; Eukaryota.
DR   InParanoid; Q6DEW6; -.
DR   OrthoDB; 1562214at2759; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023096; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IBA:GO_Central.
DR   GO; GO:0000738; P:DNA catabolic process, exonucleolytic; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034920; Rex4.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR12801:SF130; PTHR12801:SF130; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..414
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131706"
FT   DOMAIN          228..379
FT                   /note="Exonuclease"
FT   REGION          1..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..40
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  45546 MW;  C2BB37705A31DB31 CRC64;
     MAKAKVKQDQ SPSGSALGKA ANSQKQTKKQ KKKKFWKNHP KIAGKTSEAK TLFPLLPPKQ
     PQEFSSNWKA LQELLKPKLN PAAPATPSEK FPKKDQKVSE KKNGDPEPPK STPKINGGIT
     SVTPKEAKAP SQAPPTKAVE VKKEKKRKIK AEGTEQLDPP KKPQGGTQPE PPKVDIWFDD
     VDPDDIEAAL GPEAGRIARE MQGVTETAPP TAEKVLVKEK AFEGLTRTVA MDCEMVGVGL
     DGEESMLARV SIVNLFGKCV YDKYVRPTER VTDYRTAVSG IRPDDIKNGE AFKDVQAEVA
     EILRGRTLVG HAVHNDLKIL FLDHPKKAIR DTQKYKPFKE KVKSGRPSLK LLCEKILNVK
     VQTGEHCSVQ DAQAAMRLYT MEKKCWEAAI KAKYAGVTAA KAKGPQKDKQ PPAQ