ID   REXO4_YARLI             Reviewed;         291 AA.
AC   Q6CE69;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=RNA exonuclease 4;
DE            EC=3.1.-.-;
GN   Name=REX4; OrderedLocusNames=YALI0B18128g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC       in the processing of ITS1, the internal transcribed spacer localized
CC       between the 18S and 5.8S rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the REXO4 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG83296.1; -; Genomic_DNA.
DR   RefSeq; XP_501043.1; XM_501043.1.
DR   AlphaFoldDB; Q6CE69; -.
DR   SMR; Q6CE69; -.
DR   STRING; 4952.CAG83296; -.
DR   PRIDE; Q6CE69; -.
DR   EnsemblFungi; CAG83296; CAG83296; YALI0_B18128g.
DR   GeneID; 2906963; -.
DR   KEGG; yli:YALI0B18128g; -.
DR   VEuPathDB; FungiDB:YALI0_B18128g; -.
DR   HOGENOM; CLU_022453_2_0_1; -.
DR   InParanoid; Q6CE69; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   CDD; cd06144; REX4_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR037431; REX4_DEDDh_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..291
FT                   /note="RNA exonuclease 4"
FT                   /id="PRO_0000131701"
FT   DOMAIN          133..284
FT                   /note="Exonuclease"
SQ   SEQUENCE   291 AA;  32101 MW;  0108DE713D608393 CRC64;
     MFRGLIYFIN MSLSPNWKAL QASTPGGGAK GQPGDAKRNR AKAWRAKKSE NKKVVGQLDP
     GLSKAKNVAK SKVIKCQALQ IPLRARVHKN DPTRPTLGAI LQSDDAGLEE ALHAPPQPIE
     PVLARWKCAP GKFIALDCEF VGVGPNGARS ILARVSIVNY YGHVLMDEYV KPIERVTDWR
     TWVSGVTPAM VANGISFSEA QERVKRLLNG RTLIGHALIN DLAVLGLDHP RADIRDTQKP
     QYFKTVCGCK TPSLKHVMKE CVDLNIQQGE HSSVIDAQAA MLLFRCYKKE F