ID   REXO5_BOVIN             Reviewed;         783 AA.
AC   Q2T9U5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=RNA exonuclease 5;
DE            EC=3.1.-.-;
DE   AltName: Full=Putative RNA exonuclease NEF-sp;
GN   Name=REXO5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC111262; AAI11263.1; -; mRNA.
DR   RefSeq; NP_001033243.1; NM_001038154.2.
DR   RefSeq; XP_005224807.1; XM_005224750.3.
DR   RefSeq; XP_005224808.1; XM_005224751.3.
DR   AlphaFoldDB; Q2T9U5; -.
DR   SMR; Q2T9U5; -.
DR   STRING; 9913.ENSBTAP00000008458; -.
DR   PaxDb; Q2T9U5; -.
DR   PRIDE; Q2T9U5; -.
DR   Ensembl; ENSBTAT00000008458; ENSBTAP00000008458; ENSBTAG00000006449.
DR   GeneID; 532864; -.
DR   KEGG; bta:532864; -.
DR   CTD; 81691; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006449; -.
DR   VGNC; VGNC:58611; REXO5.
DR   eggNOG; KOG2248; Eukaryota.
DR   GeneTree; ENSGT00940000161162; -.
DR   HOGENOM; CLU_024781_0_0_1; -.
DR   InParanoid; Q2T9U5; -.
DR   OMA; CFLDCLQ; -.
DR   OrthoDB; 593068at2759; -.
DR   TreeFam; TF314974; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000006449; Expressed in spermatocyte and 104 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..783
FT                   /note="RNA exonuclease 5"
FT                   /id="PRO_0000287344"
FT   DOMAIN          230..378
FT                   /note="Exonuclease"
FT   DOMAIN          503..577
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          598..677
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   783 AA;  88254 MW;  98072594E44231C2 CRC64;
     MEPERKRSGS TLKKGRKRRL IPSKVVGAAE ATRSHWDLEE KQQPIAKKAR LSTVLFAENC
     EVTHGQLCEL LKYAVLGKSS FPKPSWCQLF HQNHLKNVVV FILQGLSQLH FYKFYLEFGF
     LRKAFKHKFR MPPPSSDFLA DIIGLQKKQI IGNLPKAMEG SLPFASSKVS INLQKDPIIQ
     KYGFKKVGLT RCLLTKEEMK TYHFPLQGFL DCENFVPTKC NGSVTDNSPL FGLDCEMCLT
     SKGRELTRIS LVAEGGGCVM DELVKPDNKI VDYLTSFSGI TKKILNPVTT KLKDVQRRLK
     ILLPPDAVLV GHSLDLDLRA LKMIHPYVID TSLLYVREQG RRFKLKFLAK AILGKDIQCP
     DRLGHDATED ARTTLELARY FLKYGPKKIA ELNLEALFSY QESQEPRNTA EGVQRLNTSV
     LECLDSVGQK LLFLTQEADA SALSSSKNCQ TIKCLSNKEV LEQARVEIPL FPFSIVQFSF
     EPFSPNLTQE MNKRIKIKWT EMSTVYAGPF NKNCNLSALK RLFKSFGPVQ LMTLVLETHQ
     PHLCIQYEVL EAAQLAIESL DGVLVEGSCI KVQRPVTELT LDCDTLVNEL EQDSENRGTI
     YLSGVSETFK EHLLQHCSIF LGLEAMILPK DLKSGKQKGY CFLRFKTFGS AQRALNILTG
     KDWKLRGRHA LTPRHLHAWL RGLARESRLP GVRVIPPPSE QEAWQMLNVD HPKIAAWHWG
     RKIEKLYHNL CPGTLCLILL PGTKSTHGSL SGLGLMGIKD EEESTIPQTC VCESAHHLPG
     VIS