REXO5_HUMAN
ID REXO5_HUMAN Reviewed; 774 AA.
AC Q96IC2; B2RB19; O60364; Q96MB1; Q9BXH9; Q9H0K2; Q9NSM2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=RNA exonuclease 5 {ECO:0000312|HGNC:HGNC:24661};
DE EC=3.1.-.-;
DE AltName: Full=Exonuclease NEF-sp;
GN Name=REXO5 {ECO:0000312|HGNC:HGNC:24661}; ORFNames=44M2.3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Li J.M., Sha J.H., Zhou Z.M.;
RT "Cloning of a novel exonuclease factor gene related to testis development
RT in humans.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 416-774 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96IC2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96IC2-2; Sequence=VSP_025443;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC31668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF332193; AAK17192.1; -; mRNA.
DR EMBL; AL136763; CAB66697.1; -; mRNA.
DR EMBL; AK057254; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK314458; BAG37066.1; -; mRNA.
DR EMBL; AC004381; AAC31668.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471228; EAW66838.1; -; Genomic_DNA.
DR EMBL; BC007646; AAH07646.1; -; mRNA.
DR EMBL; BC068503; AAH68503.1; -; mRNA.
DR EMBL; AL162035; CAB82386.1; -; mRNA.
DR CCDS; CCDS10591.1; -. [Q96IC2-1]
DR CCDS; CCDS45437.1; -. [Q96IC2-2]
DR PIR; T47187; T47187.
DR RefSeq; NP_001138396.1; NM_001144924.1. [Q96IC2-2]
DR RefSeq; NP_001185982.1; NM_001199053.1. [Q96IC2-1]
DR RefSeq; NP_112203.2; NM_030941.2. [Q96IC2-1]
DR RefSeq; XP_005255661.1; XM_005255604.1. [Q96IC2-1]
DR RefSeq; XP_011544265.1; XM_011545963.1. [Q96IC2-1]
DR RefSeq; XP_016879228.1; XM_017023739.1. [Q96IC2-2]
DR AlphaFoldDB; Q96IC2; -.
DR SMR; Q96IC2; -.
DR BioGRID; 123570; 29.
DR IntAct; Q96IC2; 11.
DR STRING; 9606.ENSP00000261377; -.
DR iPTMnet; Q96IC2; -.
DR PhosphoSitePlus; Q96IC2; -.
DR BioMuta; REXO5; -.
DR DMDM; 74760869; -.
DR MassIVE; Q96IC2; -.
DR MaxQB; Q96IC2; -.
DR PaxDb; Q96IC2; -.
DR PeptideAtlas; Q96IC2; -.
DR PRIDE; Q96IC2; -.
DR ProteomicsDB; 76822; -. [Q96IC2-1]
DR ProteomicsDB; 76823; -. [Q96IC2-2]
DR Antibodypedia; 25622; 38 antibodies from 14 providers.
DR DNASU; 81691; -.
DR Ensembl; ENST00000261377.11; ENSP00000261377.6; ENSG00000005189.20. [Q96IC2-1]
DR Ensembl; ENST00000348433.10; ENSP00000261378.8; ENSG00000005189.20. [Q96IC2-2]
DR Ensembl; ENST00000564274.5; ENSP00000457616.1; ENSG00000005189.20. [Q96IC2-1]
DR GeneID; 81691; -.
DR KEGG; hsa:81691; -.
DR MANE-Select; ENST00000261377.11; ENSP00000261377.6; NM_030941.3; NP_112203.2.
DR UCSC; uc002dhv.4; human. [Q96IC2-1]
DR CTD; 81691; -.
DR GeneCards; REXO5; -.
DR HGNC; HGNC:24661; REXO5.
DR HPA; ENSG00000005189; Tissue enriched (testis).
DR neXtProt; NX_Q96IC2; -.
DR OpenTargets; ENSG00000005189; -.
DR VEuPathDB; HostDB:ENSG00000005189; -.
DR eggNOG; KOG2248; Eukaryota.
DR GeneTree; ENSGT00940000161162; -.
DR HOGENOM; CLU_024781_0_0_1; -.
DR InParanoid; Q96IC2; -.
DR OMA; CFLDCLQ; -.
DR PhylomeDB; Q96IC2; -.
DR PathwayCommons; Q96IC2; -.
DR SignaLink; Q96IC2; -.
DR BioGRID-ORCS; 81691; 8 hits in 951 CRISPR screens.
DR GeneWiki; LOC81691; -.
DR GenomeRNAi; 81691; -.
DR Pharos; Q96IC2; Tdark.
DR PRO; PR:Q96IC2; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96IC2; protein.
DR Bgee; ENSG00000005189; Expressed in left testis and 119 other tissues.
DR ExpressionAtlas; Q96IC2; baseline and differential.
DR Genevisible; Q96IC2; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:LIFEdb.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW Repeat; RNA-binding.
FT CHAIN 1..774
FT /note="RNA exonuclease 5"
FT /id="PRO_0000287345"
FT DOMAIN 228..376
FT /note="Exonuclease"
FT DOMAIN 505..579
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 600..679
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 543..573
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_025443"
FT CONFLICT 18
FT /note="S -> G (in Ref. 1; AAK17192)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="F -> S (in Ref. 3; AK057254)"
FT /evidence="ECO:0000305"
FT CONFLICT 748
FT /note="S -> R (in Ref. 4; AAC31668)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 774 AA; 86886 MW; 3860D67555EDF91F CRC64;
MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL STILFTDNCE
VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF VLQGMSQLHF YRFYLEFGCL
RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY
GSKKVGLTRC LLTKEEMRTF HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK
GRELTRISLV AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI LGKDIQCPDR
LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE IQAAGQEPKN TAEVLQHPNT
SVLECLDSVG QKLLFLTRET DAGELPSSRN CQTIKCLSNK EVLEQARVEI PLFPFSIVQF
SFKAFSPVLT EEMNKRMRIK WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET
RQPHLCIQYE VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG
SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF GSAQQALNIL
TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP PFEQEALQTL KLDHPKIAAW
RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH GSLSGLGLMG IKEEEESAGP GLCS
