ID   REXO5_MACFA             Reviewed;         772 AA.
AC   Q4R9F7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=RNA exonuclease 5;
DE            EC=3.1.-.-;
DE   AltName: Full=Putative RNA exonuclease NEF-sp;
GN   Name=REXO5; ORFNames=QtsA-10054;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB168139; BAE00264.1; -; mRNA.
DR   RefSeq; NP_001271822.1; NM_001284893.1.
DR   AlphaFoldDB; Q4R9F7; -.
DR   SMR; Q4R9F7; -.
DR   STRING; 9541.XP_005591462.1; -.
DR   GeneID; 101865662; -.
DR   CTD; 81691; -.
DR   eggNOG; KOG2248; Eukaryota.
DR   OrthoDB; 593068at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..772
FT                   /note="RNA exonuclease 5"
FT                   /id="PRO_0000287346"
FT   DOMAIN          228..376
FT                   /note="Exonuclease"
FT   DOMAIN          505..579
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          600..679
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  87040 MW;  D6D4A9BFF41E33A7 CRC64;
     MEPEREGTER HPRKVRKRRQ APNKLVGAAE AMKASWDLEE SQPEAKKARL STILFTDNCE
     VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF VLQGMSQLHF YRFYLEFGCL
     RKAFRHKFRL PPPSSDFLAD IVGLQTKQRV GDLPKTMEGP LPSNAKATIN LQNDPIIQKY
     GCKKVGLTRC LLTKEEMRTF HFPLQGFPEC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK
     GRELTRISLV AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
     LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKAI LGKDIQCPDR
     LGHDATEDAR IILELAQYFL KYGPKKIAEL NLEALANHQE IQAAGQEPRN TTEILQHPNT
     SVLECLDSVG QKLLFLTRET DAGELASSRN CQTIKCLSNK EVLEQARVEI PLFPFSIVQF
     SFKAFSPILT EEMNKRMRIK WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET
     RQPHLCIQYE VLEAAQLAIE SLDGILVDGT CIKVQRPVTE LTLDCETLVN ELEGDSENQG
     SIYLFGVSET FKEQLLQEPR LFLGLGAVIL PKDLKNGKQK KYCFLKFKSF GSAQRALNIL
     TGKDWKLKGR HALTPRHLHA WLRGLPPESR RPAGLRVVPP PFEQEALQTL KLDHPKIAAW
     RWGRKIGKLY NSLCPGTLCL ILLPGTKSTH GSLSGLGLMG IKEEEESTIS GL