REXO5_MACFA
ID REXO5_MACFA Reviewed; 772 AA.
AC Q4R9F7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=RNA exonuclease 5;
DE EC=3.1.-.-;
DE AltName: Full=Putative RNA exonuclease NEF-sp;
GN Name=REXO5; ORFNames=QtsA-10054;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AB168139; BAE00264.1; -; mRNA.
DR RefSeq; NP_001271822.1; NM_001284893.1.
DR AlphaFoldDB; Q4R9F7; -.
DR SMR; Q4R9F7; -.
DR STRING; 9541.XP_005591462.1; -.
DR GeneID; 101865662; -.
DR CTD; 81691; -.
DR eggNOG; KOG2248; Eukaryota.
DR OrthoDB; 593068at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF53098; SSF53098; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Exonuclease; Hydrolase; Nuclease; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..772
FT /note="RNA exonuclease 5"
FT /id="PRO_0000287346"
FT DOMAIN 228..376
FT /note="Exonuclease"
FT DOMAIN 505..579
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 600..679
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 87040 MW; D6D4A9BFF41E33A7 CRC64;
MEPEREGTER HPRKVRKRRQ APNKLVGAAE AMKASWDLEE SQPEAKKARL STILFTDNCE
VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF VLQGMSQLHF YRFYLEFGCL
RKAFRHKFRL PPPSSDFLAD IVGLQTKQRV GDLPKTMEGP LPSNAKATIN LQNDPIIQKY
GCKKVGLTRC LLTKEEMRTF HFPLQGFPEC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK
GRELTRISLV AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKAI LGKDIQCPDR
LGHDATEDAR IILELAQYFL KYGPKKIAEL NLEALANHQE IQAAGQEPRN TTEILQHPNT
SVLECLDSVG QKLLFLTRET DAGELASSRN CQTIKCLSNK EVLEQARVEI PLFPFSIVQF
SFKAFSPILT EEMNKRMRIK WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET
RQPHLCIQYE VLEAAQLAIE SLDGILVDGT CIKVQRPVTE LTLDCETLVN ELEGDSENQG
SIYLFGVSET FKEQLLQEPR LFLGLGAVIL PKDLKNGKQK KYCFLKFKSF GSAQRALNIL
TGKDWKLKGR HALTPRHLHA WLRGLPPESR RPAGLRVVPP PFEQEALQTL KLDHPKIAAW
RWGRKIGKLY NSLCPGTLCL ILLPGTKSTH GSLSGLGLMG IKEEEESTIS GL