ID   REXO5_RAT               Reviewed;         754 AA.
AC   A1A5R7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=RNA exonuclease 5;
DE            EC=3.1.-.-;
DE   AltName: Full=Putative RNA exonuclease NEF-sp;
GN   Name=Rexo5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC128775; AAI28776.1; -; mRNA.
DR   RefSeq; NP_001073174.1; NM_001079706.1.
DR   AlphaFoldDB; A1A5R7; -.
DR   SMR; A1A5R7; -.
DR   STRING; 10116.ENSRNOP00000019654; -.
DR   CarbonylDB; A1A5R7; -.
DR   PhosphoSitePlus; A1A5R7; -.
DR   PaxDb; A1A5R7; -.
DR   PeptideAtlas; A1A5R7; -.
DR   PRIDE; A1A5R7; -.
DR   Ensembl; ENSRNOT00000019654; ENSRNOP00000019654; ENSRNOG00000014513.
DR   GeneID; 309036; -.
DR   KEGG; rno:309036; -.
DR   UCSC; RGD:1305412; rat.
DR   CTD; 81691; -.
DR   RGD; 1305412; Rexo5.
DR   eggNOG; KOG2248; Eukaryota.
DR   GeneTree; ENSGT00940000161162; -.
DR   HOGENOM; CLU_024781_0_0_1; -.
DR   InParanoid; A1A5R7; -.
DR   OrthoDB; 593068at2759; -.
DR   PhylomeDB; A1A5R7; -.
DR   PRO; PR:A1A5R7; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000014513; Expressed in testis and 18 other tissues.
DR   ExpressionAtlas; A1A5R7; baseline and differential.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..754
FT                   /note="RNA exonuclease 5"
FT                   /id="PRO_0000287347"
FT   DOMAIN          222..370
FT                   /note="Exonuclease"
FT   DOMAIN          488..562
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          583..662
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   754 AA;  86052 MW;  59A3FB83B8CB32B6 CRC64;
     MELEEEENPR KRKETPNSAL TTELDRPSWD VQDPEPQAKK ARLSTILFTD NCEVTHRQLC
     ELLKYAILGK STLPKPSWCQ LLHQKQLNNV VVFILKGMSQ LHFYRFYLEF RFLRKTFRHK
     FSLPPPTSSF LFDIIGLQKK KSARGCPRTV EGPLISATLK SSIDLQNDPI IQKYGYKNVS
     LTRCLLTKEE MKTFHFPLQG SPNCENFILL KYSGFITDSS PLFGLDCEVC LTSMGKELTR
     ISLVAEGGYC LMDELVKPDF KILDYLTSFS GITKEILNPV TTKLKDVQKL LRELLPPDAV
     LVGHCLDLDL RVLKIIHPYV IDTSLLYIGK QGRRFKLTFL AKVILGKDIQ CPNKLGHDGI
     EDARTALELV QYFLKYGPKK IAEFNLEALA ANQEQGNKEG ATHMRSVLEC LDSMGQKLLF
     LTQDIDELSS YRNCQTVKCS SNKEVLEQAR VEVPLFPFNI VQFSFRPFPP LFAEEMKNNM
     KTRWTEMSTI YAGPFSKDCN VGSLKKVFSS LGPVQSITLV LETYRPYFSI QYELLEAAQL
     AIETMNGTIL EGSCIRVHRL LTELTLECDT LVRELEQDSE NQGTIYVAGI GETFKEHLLE
     QSNLFPDLEA VILPKELKSR KQKNYCFLKF KTFNSAQVAL EVLKGKDWKL KGRNALTSRH
     LQAWLKNIHP EPSMPMGLRI VPPLLERHIF RTLKANHPKI VAWRWSRRIE KLYHSLSPGT
     FCLILLPGTK NTFGSHPGLG LMKIKEEEGG DTLL