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REX_BACMK
ID   REX_BACMK               Reviewed;         209 AA.
AC   A9VQG4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN   Name=rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN   OrderedLocusNames=BcerKBAB4_0242;
OS   Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=315730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KBAB4;
RX   PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA   Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA   Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA   Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "Extending the Bacillus cereus group genomics to putative food-borne
RT   pathogens of different toxicity.";
RL   Chem. Biol. Interact. 171:236-249(2008).
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR   EMBL; CP000903; ABY41510.1; -; Genomic_DNA.
DR   RefSeq; WP_000372704.1; NC_010184.1.
DR   AlphaFoldDB; A9VQG4; -.
DR   SMR; A9VQG4; -.
DR   STRING; 315730.BcerKBAB4_0242; -.
DR   EnsemblBacteria; ABY41510; ABY41510; BcerKBAB4_0242.
DR   GeneID; 66264654; -.
DR   KEGG; bwe:BcerKBAB4_0242; -.
DR   eggNOG; COG2344; Bacteria.
DR   HOGENOM; CLU_061534_1_1_9; -.
DR   OMA; HEQRKAG; -.
DR   Proteomes; UP000002154; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; NAD; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..209
FT                   /note="Redox-sensing transcriptional repressor Rex"
FT                   /id="PRO_1000137320"
FT   DNA_BIND        16..55
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT   BINDING         90..95
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ   SEQUENCE   209 AA;  23516 MW;  AF9C7011B7E3C913 CRC64;
     MDQQKIPQAT AKRLPLYYRF IQNLSLSGKQ RVSSAELSEA VKVDSATIRR DFSYFGALGK
     KGYGYNVNYL LSFFRETLDQ DDITRVALIG VGNLGTAFLH YNFTKNNNTK IEMAFDVSEE
     KVGTEIGGIP VYHLDELEER LSTDIQVAIL TVPATVAQSV ADRLAETNVH GILNFTPARL
     NVSENIRIHH IDLAVELQTL VYFLKNYPQ
 
 
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