ID   REX_BACTN               Reviewed;         220 AA.
AC   Q8A0Y9;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN   Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=BT_3882;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR   EMBL; AE015928; AAO78987.1; -; Genomic_DNA.
DR   RefSeq; NP_812793.1; NC_004663.1.
DR   RefSeq; WP_008760805.1; NZ_UYXG01000011.1.
DR   AlphaFoldDB; Q8A0Y9; -.
DR   SMR; Q8A0Y9; -.
DR   STRING; 226186.BT_3882; -.
DR   PaxDb; Q8A0Y9; -.
DR   PRIDE; Q8A0Y9; -.
DR   EnsemblBacteria; AAO78987; AAO78987; BT_3882.
DR   GeneID; 60925056; -.
DR   KEGG; bth:BT_3882; -.
DR   PATRIC; fig|226186.12.peg.3947; -.
DR   eggNOG; COG2344; Bacteria.
DR   HOGENOM; CLU_061534_1_0_10; -.
DR   InParanoid; Q8A0Y9; -.
DR   OMA; HEQRKAG; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..220
FT                   /note="Redox-sensing transcriptional repressor Rex"
FT                   /id="PRO_0000097886"
FT   DNA_BIND        25..64
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT   BINDING         99..104
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ   SEQUENCE   220 AA;  24759 MW;  6F27D24725EA955F CRC64;
     MAENQKIQQI DCTKVPEPTL RRLPWYLSNV KLLKQRGERF VSSTQISKEI NIDASQIAKD
     LSYVNISGRT RVGYEVDALI EVLEHFLGFT EIHKAFLFGV GSLGGALLQD SGLKHFGLEI
     VAAFDVDPTL VGTNLNGIPI YHSDDFLKKM EEYDVQIGVL TVPIEIAQCI TDMMVDGGIK
     AVWNFTPFRI RVPEDIVVQN TSLYAHLAVM FNRLNFNEIK