REX_CALS8
ID REX_CALS8 Reviewed; 219 AA.
AC A4XIT8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=Csac_1220;
OS Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T
OS 6331).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX NCBI_TaxID=351627;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A.,
RA VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J.,
RA Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M.,
RA Kengen S.M.W., Richardson P.;
RT "Genome sequence of the thermophilic hydrogen-producing bacterium
RT Caldicellulosiruptor saccharolyticus DSM 8903.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; CP000679; ABP66823.1; -; Genomic_DNA.
DR RefSeq; WP_011916759.1; NC_009437.1.
DR AlphaFoldDB; A4XIT8; -.
DR SMR; A4XIT8; -.
DR STRING; 351627.Csac_1220; -.
DR EnsemblBacteria; ABP66823; ABP66823; Csac_1220.
DR KEGG; csc:Csac_1220; -.
DR eggNOG; COG2344; Bacteria.
DR HOGENOM; CLU_061534_1_0_9; -.
DR OMA; SQVRQDF; -.
DR OrthoDB; 1872374at2; -.
DR Proteomes; UP000000256; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; NAD; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..219
FT /note="Redox-sensing transcriptional repressor Rex"
FT /id="PRO_1000065392"
FT DNA_BIND 17..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 91..96
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ SEQUENCE 219 AA; 24896 MW; 13DD8B8C8B4ACEB4 CRC64;
MFKKKNVSLA VVRRLPRYLR YVEDLLNHDI MRISSSELSQ RMGYTASQVR QDFNNFGGFG
QQGYGYSTQV LYENLVKILG LDKNFKMIIV GVGNLGQALA NYANFYKKGF RLVGLFDVDP
QKVGKSIRNI KIQHIDELKD FIKKNDVDIG VLCVPSEVAQ EVANLMVEGG IKGIWNFTAK
EIEVKDDVVV ENVHLIDSLM VLSYKLNEKL LEKQEASQK
