REX_HTL32
ID REX_HTL32 Reviewed; 182 AA.
AC Q0R5R0;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 02-JUN-2021, entry version 35.
DE RecName: Full=Protein Rex;
DE AltName: Full=Rev homolog;
DE AltName: Full=Rex-3;
GN Name=rex;
OS Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus.
OX NCBI_TaxID=402036;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16840323; DOI=10.1128/jvi.00690-06;
RA Switzer W.M., Qari S.H., Wolfe N.D., Burke D.S., Folks T.M., Heneine W.;
RT "Ancient origin and molecular features of the novel human T-lymphotropic
RT virus type 3 revealed by complete genome analysis.";
RL J. Virol. 80:7427-7438(2006).
CC -!- FUNCTION: Rex escorts unspliced gag-pro-pol and singly spliced env
CC mRNAs out of the nucleus of infected cells. These mRNAs carry a
CC recognition sequence called Rex responsive element (RxRE or XRE)
CC located at the 3' region of the long terminal repeat (LTR). This
CC function is essential since most HTLV proteins are translated from
CC unspliced or partially spliced pre-mRNAs that cannot exit the nucleus
CC by the pathway used by fully processed cellular mRNAs (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus {ECO:0000250}. Host
CC cytoplasm {ECO:0000250}. Note=The presence of both nuclear import (NLS)
CC and nuclear export (NES) signals leads to continuous shuttling between
CC the nucleus and cytoplasm. {ECO:0000250}.
CC -!- DOMAIN: The RNA-binding motif binds to the RxRE, a complex secondary
CC structure consisting of four stem loops and a long stretch of stem
CC structure, present in incompletely spliced viral pre-mRNAs. This region
CC also contains the NLS which mediates nuclear localization. These
CC overlapping functions prevent Rex bound to RxRE from undesirable return
CC to the nucleus. When Rex binds the RxRE, the NLS becomes masked while
CC the NES remains accessible (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the deltaretrovirus Rex protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAZ77660.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ093792; AAZ77660.1; ALT_SEQ; Genomic_DNA.
DR PRIDE; Q0R5R0; -.
DR Proteomes; UP000008029; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; mRNA transport; Reference proteome;
KW RNA-binding; Transport.
FT CHAIN 1..182
FT /note="Protein Rex"
FT /id="PRO_0000259787"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..71
FT /note="Homomultimerization"
FT /evidence="ECO:0000250"
FT REGION 89..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..132
FT /note="Homomultimerization"
FT /evidence="ECO:0000250"
FT MOTIF 2..19
FT /note="Nuclear localization signal, and RNA-binding (RxRE)"
FT /evidence="ECO:0000250"
FT MOTIF 83..94
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 97..121
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 182 AA; 19674 MW; 36DBA48A68693CEC CRC64;
MPKTRKQRSR RPKNQRPSTP WPISQVSDRA FSTGTLSTFS ATVYRPIGAP FLGGFVPLGY
TAMPYWPRAP NIRLPGTPSM DALSAQLYNT LSLDSPPSPP RELPAPSRFS PPQPLLRPPR
FLHPSSTPLK NTPPSETIAL NSPWESSCQP CPSPTLGSDP KTSTPCGEAP LCAFTSISSP
PP