ID   REX_LATSS               Reviewed;         208 AA.
AC   Q93ML3; Q38XD2;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN   Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; Synonyms=laaK;
GN   OrderedLocusNames=LCA_0848;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11832506; DOI=10.1099/00221287-148-2-421;
RA   Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C.,
RA   Alpert C.-A., Zagorec M.;
RT   "Physical and genetic map of the Lactobacillus sakei 23K chromosome.";
RL   Microbiology 148:421-431(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR   EMBL; AF401045; AAK92526.1; -; Genomic_DNA.
DR   EMBL; CR936503; CAI55149.1; -; Genomic_DNA.
DR   RefSeq; WP_011374551.1; NC_007576.1.
DR   AlphaFoldDB; Q93ML3; -.
DR   SMR; Q93ML3; -.
DR   STRING; 314315.LCA_0848; -.
DR   PRIDE; Q93ML3; -.
DR   EnsemblBacteria; CAI55149; CAI55149; LCA_0848.
DR   KEGG; lsa:LCA_0848; -.
DR   eggNOG; COG2344; Bacteria.
DR   HOGENOM; CLU_061534_1_1_9; -.
DR   OMA; GKPKVGY; -.
DR   OrthoDB; 1872374at2; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..208
FT                   /note="Redox-sensing transcriptional repressor Rex"
FT                   /id="PRO_0000097896"
FT   DNA_BIND        18..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT   BINDING         92..97
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ   SEQUENCE   208 AA;  22984 MW;  69D9A274F309F048 CRC64;
     MRTPKHDLPE AVAKRIPIYY RYFKLLETDG IERIKSEQLA KLVAIPSATI RRDFSYIGDL
     GRSGYGYEVS HLIQIFSAVL KADILTKMAV IGVGNLGRAL IENNFRRNDN LQITCAFDTN
     PALVGQTLNG VPIYAIDQLA TVIPAAGITT AISTVPSEAS QRSAEQLIDA GITSILNFAP
     TRLQVPRHIN VRYLDLTAEL QTLLLFEE