ID   REX_STRSU               Reviewed;         178 AA.
AC   Q8VUP4;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
DE   Flags: Fragment;
GN   Name=rex {ECO:0000255|HAMAP-Rule:MF_01131};
OS   Streptococcus suis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCTC 10234;
RX   PubMed=11807057; DOI=10.1128/jb.184.4.971-982.2002;
RA   Osaki M., Takamatsu D., Shimoji Y., Sekizaki T.;
RT   "Characterization of Streptococcus suis genes encoding proteins homologous
RT   to sortase of Gram-positive bacteria.";
RL   J. Bacteriol. 184:971-982(2002).
CC   -!- FUNCTION: Modulates transcription in response to changes in cellular
CC       NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC       {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR   EMBL; AB066353; BAB83964.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q8VUP4; -.
DR   SMR; Q8VUP4; -.
DR   STRING; 996306.SSUR61_0734; -.
DR   eggNOG; COG2344; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01131; Rex; 1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR   InterPro; IPR022876; Tscrpt_rep_Rex.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR35786; PTHR35786; 1.
DR   Pfam; PF02629; CoA_binding; 1.
DR   Pfam; PF06971; Put_DNA-bind_N; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; NAD; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..178
FT                   /note="Redox-sensing transcriptional repressor Rex"
FT                   /id="PRO_0000097924"
FT   BINDING         59..64
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT   NON_TER         1
SQ   SEQUENCE   178 AA;  19661 MW;  56607DA488B0058B CRC64;
     ASSKEIAEAI GIDSATVRRD FSYFGELGRR GFGYNVKELM DFFADILNDT SITNVMLVGV
     GNMGRALLHY RFHERNKMKI VMAFEADDNP AVGTTDENIP IHAISEIKER ISEANSQTAI
     LTVPSVKAQE VTDILVEAGV KGILSFSPVN LSVPKDVVVQ YVDLTSELQT LLYFMRKG