REX_THEAB
ID REX_THEAB Reviewed; 207 AA.
AC B7IDQ7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=THA_1697;
OS Thermosipho africanus (strain TCF52B).
OC Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX NCBI_TaxID=484019;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TCF52B;
RX PubMed=19124572; DOI=10.1128/jb.01448-08;
RA Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D.,
RA Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.;
RT "The genome of Thermosipho africanus TCF52B: lateral genetic connections to
RT the Firmicutes and Archaea.";
RL J. Bacteriol. 191:1974-1978(2009).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; CP001185; ACJ76134.1; -; Genomic_DNA.
DR RefSeq; WP_012580357.1; NC_011653.1.
DR AlphaFoldDB; B7IDQ7; -.
DR SMR; B7IDQ7; -.
DR STRING; 484019.THA_1697; -.
DR EnsemblBacteria; ACJ76134; ACJ76134; THA_1697.
DR KEGG; taf:THA_1697; -.
DR eggNOG; COG2344; Bacteria.
DR HOGENOM; CLU_061534_1_0_0; -.
DR OMA; HEQRKAG; -.
DR OrthoDB; 1872374at2; -.
DR Proteomes; UP000002453; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; NAD; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..207
FT /note="Redox-sensing transcriptional repressor Rex"
FT /id="PRO_1000137337"
FT DNA_BIND 15..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 89..94
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
SQ SEQUENCE 207 AA; 23579 MW; EFBBE246FC0030C3 CRC64;
MEKKIPRPVI KRLGLYYRCL NRLYEEGIEY VASKDIAERL GIKSSQVRKD LSYFGEFGKR
GVGYNTYELM ERLEDIIGVN KYWNVIVIGA GNIGSAIANY EGLRKEKFNV IGIFDADRSK
VGRKIGRLIV KHFSEIDDFF KKNIVEIAVL AVPENAAQMV VDKLEELGIK GIVNFAPVKL
RTNIPVEDVD ITLSFKSLSF KIERNIE