REX_THET2
ID REX_THET2 Reviewed; 211 AA.
AC Q72I39;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000255|HAMAP-Rule:MF_01131};
GN Name=rex {ECO:0000255|HAMAP-Rule:MF_01131}; OrderedLocusNames=TT_C1293;
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000255|HAMAP-Rule:MF_01131}.
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DR EMBL; AE017221; AAS81635.1; -; Genomic_DNA.
DR RefSeq; WP_011173693.1; NC_005835.1.
DR PDB; 3IKT; X-ray; 2.26 A; A/B=1-206.
DR PDB; 3IKV; X-ray; 2.40 A; A/B=1-206.
DR PDB; 3IL2; X-ray; 2.49 A; A/B=1-206.
DR PDBsum; 3IKT; -.
DR PDBsum; 3IKV; -.
DR PDBsum; 3IL2; -.
DR AlphaFoldDB; Q72I39; -.
DR SMR; Q72I39; -.
DR STRING; 262724.TT_C1293; -.
DR EnsemblBacteria; AAS81635; AAS81635; TT_C1293.
DR GeneID; 3168513; -.
DR KEGG; tth:TT_C1293; -.
DR eggNOG; COG2344; Bacteria.
DR HOGENOM; CLU_061534_1_0_0; -.
DR OMA; HEQRKAG; -.
DR OrthoDB; 1872374at2; -.
DR EvolutionaryTrace; Q72I39; -.
DR Proteomes; UP000000592; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; PTHR35786; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; NAD; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..211
FT /note="Redox-sensing transcriptional repressor Rex"
FT /id="PRO_1000065428"
FT DNA_BIND 13..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT BINDING 87..92
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01131"
FT HELIX 5..24
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 31..38
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 42..50
FT /evidence="ECO:0007829|PDB:3IKT"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 64..74
FT /evidence="ECO:0007829|PDB:3IKT"
FT TURN 76..78
FT /evidence="ECO:0007829|PDB:3IKV"
FT STRAND 81..86
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 90..96
FT /evidence="ECO:0007829|PDB:3IKT"
FT TURN 102..104
FT /evidence="ECO:0007829|PDB:3IKV"
FT STRAND 105..112
FT /evidence="ECO:0007829|PDB:3IKT"
FT TURN 115..119
FT /evidence="ECO:0007829|PDB:3IKT"
FT STRAND 125..129
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 130..135
FT /evidence="ECO:0007829|PDB:3IKT"
FT TURN 138..140
FT /evidence="ECO:0007829|PDB:3IKT"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 153..162
FT /evidence="ECO:0007829|PDB:3IKT"
FT STRAND 166..170
FT /evidence="ECO:0007829|PDB:3IKT"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:3IKT"
FT STRAND 182..186
FT /evidence="ECO:0007829|PDB:3IKT"
FT HELIX 189..201
FT /evidence="ECO:0007829|PDB:3IKT"
FT TURN 203..205
FT /evidence="ECO:0007829|PDB:3IKT"
SQ SEQUENCE 211 AA; 23222 MW; A49C2755DDB1D7EC CRC64;
MKVPEAAISR LITYLRILEE LEAQGVHRTS SEQLGELAQV TAFQVRKDLS YFGSYGTRGV
GYTVPVLKRE LRHILGLNRK WGLCIVGMGR LGSALADYPG FGESFELRGF FDVDPEKVGR
PVRGGVIEHV DLLPQRVPGR IEIALLTVPR EAAQKAADLL VAAGIKGILN FAPVVLEVPK
EVAVENVDFL AGLTRLSFAI LNPKWREEMM G
