ID   RF11_METAC              Reviewed;         415 AA.
AC   Q8TUM4;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Peptide chain release factor subunit 1-1 {ECO:0000255|HAMAP-Rule:MF_00424};
DE   AltName: Full=Translation termination factor aRF1 1 {ECO:0000255|HAMAP-Rule:MF_00424};
GN   Name=prf11 {ECO:0000255|HAMAP-Rule:MF_00424}; Synonyms=erf1;
GN   OrderedLocusNames=MA_0042;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00424}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00424}.
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DR   EMBL; AE010299; AAM03496.1; -; Genomic_DNA.
DR   RefSeq; WP_011020101.1; NC_003552.1.
DR   AlphaFoldDB; Q8TUM4; -.
DR   SMR; Q8TUM4; -.
DR   STRING; 188937.MA_0042; -.
DR   EnsemblBacteria; AAM03496; AAM03496; MA_0042.
DR   GeneID; 1471934; -.
DR   KEGG; mac:MA_0042; -.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   InParanoid; Q8TUM4; -.
DR   OMA; GQEMEVV; -.
DR   OrthoDB; 32191at2157; -.
DR   PhylomeDB; Q8TUM4; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IBA:GO_Central.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..415
FT                   /note="Peptide chain release factor subunit 1-1"
FT                   /id="PRO_0000143172"
SQ   SEQUENCE   415 AA;  46175 MW;  1CA97F0DA312DEB4 CRC64;
     MTEQSAHEKY EFKKKLESLR DKKGRSTELI SLYIPADKQI FDVTNQLKDE HGQAANIKSK
     LTRTNVQGAI ESLLSRLRYL DKVPENGIVY FTGAVDIGAN KTSMESEVII PPEPITVYKY
     HCDSSFYLEP LEDMLKDKST FGLLVLDRRE ATIGLLVGKR IQAFRNLTST VPGKQRKGGQ
     SAHRFQQLRL IAIHDFYKRI GDAASEIFMA VDHKDLKGVL IGGPSPTKEE FYGGEFLHHE
     LQKKILGLFD TAYTDESGLS ELVNAAGEKL QDLELMGQKN AVRDFFKELI ADSGKVAYGE
     TQVRANLEIN AVDVLLLSED LRAERVTTKC SVCGYENKWT RRWKPGEPAP TAGNCPKCGS
     SLEVTDVIDV VDEFSELADK SNAKVVFVST DFDEGSQLMN AFGGIAAILR YSTGV