ID   RF1ML_BOVIN             Reviewed;         380 AA.
AC   Q2KI15;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Peptide chain release factor 1-like, mitochondrial;
DE   AltName: Full=Mitochondrial translational release factor 1-like;
DE   Flags: Precursor;
GN   Name=MTRF1L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial peptide chain release factor that directs the
CC       termination of translation in response to the peptide chain termination
CC       codons UAA and UAG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- PTM: Methylation of glutamine in the GGQ triplet is conserved from
CC       bacteria to mammals. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000305}.
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DR   EMBL; BC112806; AAI12807.1; -; mRNA.
DR   RefSeq; NP_001039843.1; NM_001046378.1.
DR   AlphaFoldDB; Q2KI15; -.
DR   SMR; Q2KI15; -.
DR   STRING; 9913.ENSBTAP00000012219; -.
DR   PaxDb; Q2KI15; -.
DR   PRIDE; Q2KI15; -.
DR   GeneID; 534354; -.
DR   KEGG; bta:534354; -.
DR   CTD; 54516; -.
DR   eggNOG; KOG2726; Eukaryota.
DR   InParanoid; Q2KI15; -.
DR   OrthoDB; 1313171at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR   GO; GO:0070126; P:mitochondrial translational termination; IBA:GO_Central.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Methylation; Mitochondrion; Protein biosynthesis;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..380
FT                   /note="Peptide chain release factor 1-like, mitochondrial"
FT                   /id="PRO_0000330943"
FT   COILED          63..118
FT                   /evidence="ECO:0000255"
FT   MOD_RES         252
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   380 AA;  43523 MW;  CBFB7F2C5797299C CRC64;
     MRPRLVWNVF RGFWARRGVV PACRHLSCSN LPLEELFARG GALRTFLERQ VGAEAQFQVR
     RPELVAVAKL LSDKEQELQE TQHLLHDENE DLRKLAENEI TSCEKEIAQL KHQIILLLVP
     SEETDKNDLI LEVTAGVGGQ EAMLFTSEIF DMYQQYAAFK RWHFETLEYF PSEIGGLRHA
     SASIGGSEAY KHMKFEGGVH RVQRVPKTEK QGRIHTSTMT VAILPQPTEI NLVINPKDLR
     IDTKRASGAG GQHVNTTDSA VRIVHLPTGI VSECQQERSQ LKNKEMAMKK LRAKLYSLQL
     EEETSKRYNA RKIQIGTKGR SEKIRTYNFP QNRVTDHRIN KSLHDLETFM QGEYLLDELV
     QSLKDYANYE SLVEIIAKEV