RF1ML_MOUSE
ID RF1ML_MOUSE Reviewed; 373 AA.
AC Q8BJU9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Peptide chain release factor 1-like, mitochondrial;
DE AltName: Full=Mitochondrial translational release factor 1-like;
DE Flags: Precursor;
GN Name=Mtrf1l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, and Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Mitochondrial peptide chain release factor that directs the
CC termination of translation in response to the peptide chain termination
CC codons UAA and UAG. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- PTM: Methylation of glutamine in the GGQ triplet is conserved from
CC bacteria to mammals. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000305}.
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DR EMBL; AK036424; BAE20502.1; -; mRNA.
DR EMBL; AK078897; BAC37446.1; -; mRNA.
DR CCDS; CCDS56684.1; -.
DR RefSeq; NP_780583.1; NM_175374.3.
DR AlphaFoldDB; Q8BJU9; -.
DR SMR; Q8BJU9; -.
DR STRING; 10090.ENSMUSP00000019908; -.
DR PhosphoSitePlus; Q8BJU9; -.
DR EPD; Q8BJU9; -.
DR MaxQB; Q8BJU9; -.
DR PaxDb; Q8BJU9; -.
DR PeptideAtlas; Q8BJU9; -.
DR PRIDE; Q8BJU9; -.
DR ProteomicsDB; 253216; -.
DR Antibodypedia; 33386; 234 antibodies from 15 providers.
DR DNASU; 108853; -.
DR Ensembl; ENSMUST00000019908; ENSMUSP00000019908; ENSMUSG00000019774.
DR GeneID; 108853; -.
DR KEGG; mmu:108853; -.
DR UCSC; uc007egi.1; mouse.
DR CTD; 54516; -.
DR MGI; MGI:1918830; Mtrf1l.
DR VEuPathDB; HostDB:ENSMUSG00000019774; -.
DR eggNOG; KOG2726; Eukaryota.
DR GeneTree; ENSGT00940000155683; -.
DR HOGENOM; CLU_036856_0_3_1; -.
DR InParanoid; Q8BJU9; -.
DR OMA; ISDHRVG; -.
DR OrthoDB; 1313171at2759; -.
DR PhylomeDB; Q8BJU9; -.
DR TreeFam; TF313720; -.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 108853; 22 hits in 73 CRISPR screens.
DR ChiTaRS; Mtrf1l; mouse.
DR PRO; PR:Q8BJU9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BJU9; protein.
DR Bgee; ENSMUSG00000019774; Expressed in embryonic post-anal tail and 222 other tissues.
DR Genevisible; Q8BJU9; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR GO; GO:0070126; P:mitochondrial translational termination; IBA:GO_Central.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Methylation; Mitochondrion; Protein biosynthesis;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..25
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 26..373
FT /note="Peptide chain release factor 1-like, mitochondrial"
FT /id="PRO_0000330945"
FT COILED 56..110
FT /evidence="ECO:0000255"
FT MOD_RES 245
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 373 AA; 42248 MW; 726392BED81EC36B CRC64;
MRSGFLSGAR RLWARRAFSR TPPPSEELLA RGGPLRAFLE RRVGSEAGGL DAGYPQLAAA
ARLLSEKERE LRDTESLLHD ENEDLKKLAE SEIALCQKQI TELKHQIISL LVPSEEMDGS
DLILEVTAGV GGQEAMLFTS EMFDMYQQYA AFKRWHFETL EYFPSELGGL RHASASVGGP
EAYRHMKFEG GVHRVQRVPK TEKQGRIHTS TMTVAILPQP TEIKLVINPK DLRIDTKRAS
GAGGQHVNTT DSAVRIVHLP TGIISECQQE RSQLKNRELA MKKLRARLYS MHLEEETAKR
YNARKIQVGT KGRSEKIRTY NFPQNRVTDH RINKSLHDLE SFMQGDCLLD DMIQSLKDCS
DYEALVEMIS RRD
