ID   RF1ML_RAT               Reviewed;         373 AA.
AC   Q4V7E5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Peptide chain release factor 1-like, mitochondrial;
DE   AltName: Full=Mitochondrial translational release factor 1-like;
DE   Flags: Precursor;
GN   Name=Mtrf1l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Mitochondrial peptide chain release factor that directs the
CC       termination of translation in response to the peptide chain termination
CC       codons UAA and UAG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- PTM: Methylation of glutamine in the GGQ triplet is conserved from
CC       bacteria to mammals. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097970; AAH97970.1; -; mRNA.
DR   RefSeq; NP_001020894.1; NM_001025723.1.
DR   AlphaFoldDB; Q4V7E5; -.
DR   SMR; Q4V7E5; -.
DR   STRING; 10116.ENSRNOP00000025398; -.
DR   PaxDb; Q4V7E5; -.
DR   PRIDE; Q4V7E5; -.
DR   GeneID; 361473; -.
DR   KEGG; rno:361473; -.
DR   UCSC; RGD:1598312; rat.
DR   CTD; 54516; -.
DR   RGD; 1598312; Mtrf1l.
DR   VEuPathDB; HostDB:ENSRNOG00000018773; -.
DR   eggNOG; KOG2726; Eukaryota.
DR   HOGENOM; CLU_036856_0_3_1; -.
DR   InParanoid; Q4V7E5; -.
DR   OMA; ISDHRVG; -.
DR   OrthoDB; 1313171at2759; -.
DR   PhylomeDB; Q4V7E5; -.
DR   TreeFam; TF313720; -.
DR   Reactome; R-RNO-5419276; Mitochondrial translation termination.
DR   PRO; PR:Q4V7E5; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000018773; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; Q4V7E5; RN.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR   GO; GO:0070126; P:mitochondrial translational termination; IBA:GO_Central.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Methylation; Mitochondrion; Protein biosynthesis;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..13
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..373
FT                   /note="Peptide chain release factor 1-like, mitochondrial"
FT                   /id="PRO_0000330946"
FT   COILED          56..111
FT                   /evidence="ECO:0000255"
FT   MOD_RES         245
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   373 AA;  42343 MW;  3399053A62C1B9C5 CRC64;
     MRSGFLRSAR RLWARRAISR MPPPSEELLA RGGPLRAFLE RRVGSEAGGL DAGSPQLAAA
     ARLLNEKERE LRDTESLLHD ENEDLKKLAE SEIALCQKEI AELKHRIISL LVPSEDMDGS
     DLILEVTAGV GGQEAMLFTS EMFDMYQQYA AFKRWHFETL EYFPSELGGL RHASASIGGP
     EAYRHMKFEG GVHRVQRVPK TERQGRIHTS TMTVAILPQP TEIKLVINPK DLRIDTKRAS
     GAGGQHVNTT DSAVRIVHLP TGIISECQQE RSQLKNRELA MKKLRARLYS MRLEEETAKR
     YSARKIQVGT KGRSEKIRTY NFPQNRVTDH RINKSLHDLE SFMQGDCLLD DLIQSLKDYS
     DYESLVEMIS RKD