RF1M_CAEEL
ID RF1M_CAEEL Reviewed; 389 AA.
AC O44568;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable peptide chain release factor 1, mitochondrial;
DE Short=MRF-1;
DE Short=MtRF-1;
DE Flags: Precursor;
GN ORFNames=W03F8.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Mitochondrial peptide chain release factor that directs the
CC termination of translation in response to the peptide chain termination
CC codons UAA and UAG. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- PTM: Methylation of glutamine in the GGQ triplet is conserved from
CC bacteria to mammals. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000305}.
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DR EMBL; FO080652; CCD65509.1; -; Genomic_DNA.
DR PIR; T15102; T15102.
DR RefSeq; NP_500737.1; NM_068336.6.
DR AlphaFoldDB; O44568; -.
DR SMR; O44568; -.
DR BioGRID; 42419; 1.
DR STRING; 6239.W03F8.3; -.
DR EPD; O44568; -.
DR PaxDb; O44568; -.
DR PeptideAtlas; O44568; -.
DR EnsemblMetazoa; W03F8.3a.1; W03F8.3a.1; WBGene00020993.
DR UCSC; W03F8.3; c. elegans.
DR WormBase; W03F8.3a; CE17273; WBGene00020993; -.
DR eggNOG; KOG2726; Eukaryota.
DR HOGENOM; CLU_036856_0_3_1; -.
DR InParanoid; O44568; -.
DR OMA; NWKDSRC; -.
DR OrthoDB; 1313171at2759; -.
DR PhylomeDB; O44568; -.
DR Reactome; R-CEL-5419276; Mitochondrial translation termination.
DR PRO; PR:O44568; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00020993; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; O44568; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003747; F:translation release factor activity; IEA:InterPro.
DR GO; GO:0070126; P:mitochondrial translational termination; IBA:GO_Central.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Methylation; Mitochondrion; Protein biosynthesis; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..389
FT /note="Probable peptide chain release factor 1,
FT mitochondrial"
FT /id="PRO_0000030335"
FT MOD_RES 259
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 389 AA; 43494 MW; B41E9D42C82C3598 CRC64;
MLKRHQQLLF RLIRQSVLHQ SSPTSSSASS TLLNSENGEK FVKTVVDRLA QCQAGNATAA
PEQISYWESI SKQSAKVSDG RSELSQLRTI INDPKETEEM RKLAEVDVES IEENLETELQ
ELAVKIVPLN NLDVLSKCQI ELSCGAGGQE AMLFTGELLD MYQKLAAVNS WKWDPLQVDN
VPLGGVRSAL IAVSGEKVYA KMRFEAGVHR VQRVPVNDSR MHTSTASISV LPEPEEVSVV
VPSDSVKIEA MRASGPGGQN VNKRSTAVRM THKETGIAVH CMDERFQHLN IQIAYKRLAA
ILMQKQVDAM LEKIVSKRKL QVGSKARAEK IRTYNFQHDR VTDHRIQMSI TGVAEFLSAG
ETLQTMIERL QEQHLEDRLD HIIENCIVE
