ID   RF1_ACICJ               Reviewed;         352 AA.
AC   A5FX99;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=Acry_1014;
OS   Acidiphilium cryptum (strain JF-5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Acidiphilium.
OX   NCBI_TaxID=349163;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JF-5;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.;
RT   "Complete sequence of chromosome of Acidiphilium cryptum JF-5.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; CP000697; ABQ30231.1; -; Genomic_DNA.
DR   RefSeq; WP_011941928.1; NC_009484.1.
DR   AlphaFoldDB; A5FX99; -.
DR   SMR; A5FX99; -.
DR   STRING; 349163.Acry_1014; -.
DR   EnsemblBacteria; ABQ30231; ABQ30231; Acry_1014.
DR   KEGG; acr:Acry_1014; -.
DR   eggNOG; COG0216; Bacteria.
DR   HOGENOM; CLU_036856_0_8_5; -.
DR   OMA; ISDHRVG; -.
DR   OrthoDB; 928964at2; -.
DR   Proteomes; UP000000245; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..352
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_1000004853"
FT   MOD_RES         229
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   352 AA;  39103 MW;  E3D7035506F93618 CRC64;
     MTLEQKLDRI VLRAEELRAM LAAGVDGERF VAASRELAEI EPVEQQILLL RAAERARDEA
     EAARADPELR ELADAELDSL RETLPRLEHE IRLALLPRDA ADERPAILEI RPAAGGDEAA
     LFAAELFAAY RRYADLRGWR FEILDYTETE LGGLREGIAE ITGRAVFARL KFESGVHRVQ
     RVPATETQGR IHTSTVTVAV LPEAEDVDVE VNEADLRIDV FRASGAGGQH VNKTESAVRI
     THLPTGIVVA MQEERSQHKN RAKAMKILRA RLYEQTRAAA AAGRAADRKS QVGTGDRSER
     IRTYNFPQGR VTDHRINLTL HKIDRVMLGE FDEIIDALTE EDQAARLAAA GA