ID   RF1_BACFR               Reviewed;         370 AA.
AC   Q64XW5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=BF0910;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; AP006841; BAD47661.1; -; Genomic_DNA.
DR   RefSeq; WP_005785133.1; NC_006347.1.
DR   RefSeq; YP_098195.1; NC_006347.1.
DR   AlphaFoldDB; Q64XW5; -.
DR   SMR; Q64XW5; -.
DR   STRING; 295405.BF0910; -.
DR   EnsemblBacteria; BAD47661; BAD47661; BF0910.
DR   GeneID; 66330107; -.
DR   KEGG; bfr:BF0910; -.
DR   PATRIC; fig|295405.11.peg.913; -.
DR   HOGENOM; CLU_036856_0_1_10; -.
DR   OMA; ISDHRVG; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis.
FT   CHAIN           1..370
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_0000177629"
FT   MOD_RES         239
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   370 AA;  41656 MW;  F785630993AE988A CRC64;
     MADNNSILEK LDGLVARFEE VSTLITDPAV IADQKRYVKL TKEYKELDDL MKARKEYMQL
     LANIEEAKDI LSNESDADMR EMAKEEMDNS QERLPVLEEE IKLLLVPADP QDGKNAILEI
     RGGTGGDEAA IFAGDLFRMY AKFCETKGWK MEVSSANEGA AGGYKEIICS VTGDNVYGTL
     KYESGVHRVQ RVPATETQGR VHTSAASVAV LPEAEEFDVV INEGEIKWDT FRSGGAGGQN
     VNKVESGVRL RYIWKNPNTG VAEEILIECT ETRDQPKNKE RALARLRTFI YDKEHQKYID
     DIASKRKTMV STGDRSAKIR TYNYPQGRIT DHRINYTIYN LAAFMDGDIQ ECIDKLTVAE
     NAERLKESEL