ID   RF1_BACTN               Reviewed;         370 AA.
AC   Q8A011;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=BT_4210;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015928; AAO79315.1; -; Genomic_DNA.
DR   RefSeq; NP_813121.1; NC_004663.1.
DR   RefSeq; WP_008759884.1; NZ_UYXG01000012.1.
DR   AlphaFoldDB; Q8A011; -.
DR   SMR; Q8A011; -.
DR   STRING; 226186.BT_4210; -.
DR   PaxDb; Q8A011; -.
DR   PRIDE; Q8A011; -.
DR   EnsemblBacteria; AAO79315; AAO79315; BT_4210.
DR   GeneID; 60925383; -.
DR   KEGG; bth:BT_4210; -.
DR   PATRIC; fig|226186.12.peg.4277; -.
DR   eggNOG; COG0216; Bacteria.
DR   HOGENOM; CLU_036856_0_1_10; -.
DR   InParanoid; Q8A011; -.
DR   OMA; ISDHRVG; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..370
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_0000177634"
FT   MOD_RES         239
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   370 AA;  41662 MW;  17487777C55D5577 CRC64;
     MADNSTILEK LDGLVARFEE ISTLITDPAV IADQKRYVKL TKEYKDLDDL MKARKEYIQL
     LGNIEEAKNI LSNESDADMR EMAKEEMDNS QERLPALEEE IKLMLVPADP QDSKNAILEI
     RGGAGGDEAA IFAGDLFRMY AKFCETKGWK MEVSNANEGT AGGYKEIVCS VTGDNVYGIL
     KYESGVHRVQ RVPATETQGR VHTSAASVAV LPEAEEFDVV INEGEIKWDT FRSGGAGGQN
     VNKVESGVRL RYIWKNPNTG VAEEILIECT ETRDQPKNKE RALARLRTFI YDKEHQKYID
     DIASKRKTMV STGDRSAKIR TYNYPQGRIT DHRINYTIYN LAAFMDGDIQ DCIDHLIVAE
     NAERLKESEL