ID   RF1_BIFA0               Reviewed;         365 AA.
AC   B8DTL4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=BLA_1055;
OS   Bifidobacterium animalis subsp. lactis (strain AD011).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=442563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AD011;
RX   PubMed=19011029; DOI=10.1128/jb.01515-08;
RA   Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H.,
RA   Kim D.-W., Ji G.E., Park H.-S., Oh T.K.;
RT   "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp.
RT   lactis AD011.";
RL   J. Bacteriol. 191:678-679(2009).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; CP001213; ACL29343.1; -; Genomic_DNA.
DR   RefSeq; WP_004218748.1; NC_011835.1.
DR   AlphaFoldDB; B8DTL4; -.
DR   SMR; B8DTL4; -.
DR   STRING; 442563.BLA_1055; -.
DR   EnsemblBacteria; ACL29343; ACL29343; BLA_1055.
DR   GeneID; 66532884; -.
DR   KEGG; bla:BLA_1055; -.
DR   PATRIC; fig|442563.4.peg.1103; -.
DR   HOGENOM; CLU_036856_0_1_11; -.
DR   OMA; ISDHRVG; -.
DR   Proteomes; UP000002456; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_1000193470"
FT   MOD_RES         240
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   365 AA;  40948 MW;  78FD6734FD62C3D4 CRC64;
     MASEEFPAAK TALEEYENIE RQMGEQEVWS NPDKMRKLGR RQAQLGTIVN AYRTWLNIRN
     DLDAAQEMAG EDPDFAQEAK RLESELPEAE EKLRTALIPR DPDDARDVIM EIKAGAGGEE
     AALFAGDLLR MYMRYAEKRG WGVTIQSENS TELGGVKDVQ MAIRAKGNPS PEEGVWASLK
     YEGGVHRVQR IPVTESQGRI QTSAAGVIVF PEADEDDDEI EIDPKDLKID IFMSSGPGGQ
     SVNTTYSAVR MTHIPTGIVV SMQDEKSQIQ NRAAALRVLK SRLLAMKHEQ EAAEAADMRH
     SQVRSLDRSE RIRTYNFPEN RIVDHRTNYK AYNLDAVLDG DLQAVIDSDI QADEEQRLAS
     QQQQQ