ID   RF1_BIFAA               Reviewed;         362 AA.
AC   A1A0I9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=BAD_0441;
OS   Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 /
OS   E194a).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=367928;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15703 / DSM 20083 / NCTC 11814 / E194a;
RA   Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S., Hirai S.,
RA   Tanaka K., Watanabe K.;
RT   "Bifidobacterium adolescentis complete genome sequence.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; AP009256; BAF39222.1; -; Genomic_DNA.
DR   RefSeq; WP_003808375.1; NC_008618.1.
DR   AlphaFoldDB; A1A0I9; -.
DR   SMR; A1A0I9; -.
DR   STRING; 1680.BADO_0456; -.
DR   EnsemblBacteria; BAF39222; BAF39222; BAD_0441.
DR   GeneID; 56674516; -.
DR   KEGG; bad:BAD_0441; -.
DR   HOGENOM; CLU_036856_0_1_11; -.
DR   OMA; ISDHRVG; -.
DR   Proteomes; UP000008702; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..362
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_1000093424"
FT   MOD_RES         240
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   362 AA;  40213 MW;  9B1E3AC08C545814 CRC64;
     MADEQFPAAV TALEEYHNIE QQMAEPEVAS NPDKMRKLGR RHAELGAIVS AYTAYKQVKD
     DLEAAREMAS EDPDFAEEAK RLEGELPAAE EKLRTALIPR DPDDARDTIM EIKAGTGGEE
     AALFAGDLLR MYMRYAEKRG WSVTVQSENT TELGGVKDVQ LAIRAKGTPA PEDGVWASLK
     YEGGVHRVQR IPVTESQGRI QTSAAGVIVF PEADEDDDEI EIDPKDLKID IFMSSGPGGQ
     SVNTTYSAVR MTHIPTGITV NMQDEKSQIQ NRAAALRVLK SRLLAMKHEQ EAAEAADMRH
     SQVRSLDRSE RIRTYNFPEN RIVDHRTNYK AYNLDAVLDG DLQAVIDSDI QADEADRLAN
     QK