RF1_CAUVC
ID RF1_CAUVC Reviewed; 356 AA.
AC Q9A9V5;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Peptide chain release factor 1;
DE Short=RF-1;
GN Name=prfA; OrderedLocusNames=CC_0856;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK22841.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005673; AAK22841.1; ALT_INIT; Genomic_DNA.
DR PIR; E87355; E87355.
DR RefSeq; NP_419673.1; NC_002696.2.
DR RefSeq; WP_024265638.1; NC_002696.2.
DR AlphaFoldDB; Q9A9V5; -.
DR SMR; Q9A9V5; -.
DR STRING; 190650.CC_0856; -.
DR EnsemblBacteria; AAK22841; AAK22841; CC_0856.
DR KEGG; ccr:CC_0856; -.
DR PATRIC; fig|190650.5.peg.869; -.
DR eggNOG; COG0216; Bacteria.
DR HOGENOM; CLU_036856_0_1_5; -.
DR OMA; ISDHRVG; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00019; prfA; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT CHAIN 1..356
FT /note="Peptide chain release factor 1"
FT /id="PRO_0000177653"
FT REGION 279..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 230
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 356 AA; 39460 MW; 375DA63CBF242D86 CRC64;
MRLPQARLDQ VLDRFREVEA RMGAATDGAE IVKLSKEHAE LRPVAEAVER LAKLSAERAE
LDVMASDPEM AEMVRDEIQA LDEKLPVMER ELALMLAPKD KDENASAILE VRAGTGGDEA
ALFAGDLFRM YQRYAQTQGW RVEIDSISEG EMGGFKEIVA SITGDGVFGR LKFESGVHRV
QRVPATEAQG RIHTSAATVA VLPEAEDVEI EIKESDLRID TYRSSGAGGQ HVNKTDSAVR
ITHLPTGVVV TSSEKSQHQN RARAMKNLKA RLYDMQREAL DSARSEARKS QVGSGDRSER
IRTYNFPQGR VTDHRINLTL YNLARIMEGD ALDDVINPLI AEDQAERLAS LEESFS
