ID   RF1_CORGB               Reviewed;         358 AA.
AC   A4QDG1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=cgR_1279;
OS   Corynebacterium glutamicum (strain R).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=340322;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R;
RX   PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA   Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA   Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT   "Comparative analysis of the Corynebacterium glutamicum group and complete
RT   genome sequence of strain R.";
RL   Microbiology 153:1042-1058(2007).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; AP009044; BAF54258.1; -; Genomic_DNA.
DR   RefSeq; WP_003854866.1; NC_009342.1.
DR   AlphaFoldDB; A4QDG1; -.
DR   SMR; A4QDG1; -.
DR   EnsemblBacteria; BAF54258; BAF54258; cgR_1279.
DR   GeneID; 58309940; -.
DR   KEGG; cgt:cgR_1279; -.
DR   HOGENOM; CLU_036856_0_6_11; -.
DR   OMA; ISDHRVG; -.
DR   PhylomeDB; A4QDG1; -.
DR   Proteomes; UP000006698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis.
FT   CHAIN           1..358
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_1000004885"
FT   MOD_RES         236
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   358 AA;  39677 MW;  D7AD54FAF87A4AE0 CRC64;
     MASQVSAVDD ILSEYHGLEQ QMADPELHND AAAARRVGKR YSELQPIINV HRDLVSAQED
     LEAAREMAHE DHEFQAEAER LEVEVVELEE KLADLLAPRD PHDGEDIVME IKAGAGGEEA
     ALFAGDLLRM YQKFADKHGF VVEVLDSAES DLGGVKDITL SIRSRQPSRD GAWSQFKFEG
     GVHRVQRVPV TESQGRIQTS AAGVLVYPEP DEVENVEIDE KDIRVDVYRS SGKGGQGVNT
     TDSAVRITHL PTGLVVTCQK ERSQIQNRAR AMQVLAARLQ AMKEEEAAAE AATGRAAQIR
     TMDRSERIRT YNWPENRISD HRIGFKANNL DSVLDGELDD LFTALQAAER AERLEAEG