ID   RF1_DICTD               Reviewed;         367 AA.
AC   B8E003;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=Dtur_0805;
OS   Dictyoglomus turgidum (strain DSM 6724 / Z-1310).
OC   Bacteria; Dictyoglomi; Dictyoglomales; Dictyoglomaceae; Dictyoglomus.
OX   NCBI_TaxID=515635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6724 / Z-1310;
RX   PubMed=28066333; DOI=10.3389/fmicb.2016.01979;
RA   Brumm P.J., Gowda K., Robb F.T., Mead D.A.;
RT   "The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM
RT   6724 reveals a specialized carbohydrate fermentor.";
RL   Front. Microbiol. 7:1979-1979(2016).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; CP001251; ACK42086.1; -; Genomic_DNA.
DR   RefSeq; WP_012583170.1; NC_011661.1.
DR   RefSeq; YP_002352700.1; NC_011661.1.
DR   AlphaFoldDB; B8E003; -.
DR   SMR; B8E003; -.
DR   STRING; 515635.Dtur_0805; -.
DR   EnsemblBacteria; ACK42086; ACK42086; Dtur_0805.
DR   KEGG; dtu:Dtur_0805; -.
DR   PATRIC; fig|515635.4.peg.843; -.
DR   eggNOG; COG0216; Bacteria.
DR   HOGENOM; CLU_036856_0_1_0; -.
DR   InParanoid; B8E003; -.
DR   OMA; ISDHRVG; -.
DR   OrthoDB; 928964at2; -.
DR   Proteomes; UP000007719; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..367
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_1000117237"
FT   MOD_RES         238
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   367 AA;  42486 MW;  D245F84DD286839F CRC64;
     MLQKLVIDKL EEIEKRFEEI EGLLAKEDVI SDFNKYQSLL KERAKIEEIV DKFREYKRLL
     KEKEDLEEMV KEEQDEDLRS LAETELEDIQ EKLEKVEFEL KALLLPKDPN DEKNIIMEIR
     AGTGGEEAAL FAADLFRMYL GYAQKKGWKV EIVSSNPTGL GGFKEIIFIV EGKGAYSRLK
     FESGVHRVQR VPITESSGRI HTSTATVAVL PEMEEIEVEI DPKDLRIETF RSGGAGGQHV
     NKTESGVRIT HIPSGIVVQC QDERSQHQNR EKAMKVLRAR LYEYYQREKE NEIASQRRQQ
     VGTGERSEKI RTYNFPQRRV TDHRINYSSF QLEEVLSGEL DEFIDRLILA EKEEQIKKLF
     EEVGATS