RF1_ENDTX
ID RF1_ENDTX Reviewed; 356 AA.
AC B1GZI5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=TGRD_184;
OS Endomicrobium trichonymphae.
OC Bacteria; Elusimicrobia; Endomicrobia; Endomicrobiales; Endomicrobiaceae;
OC Endomicrobium.
OX NCBI_TaxID=1408204;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=18391199; DOI=10.1073/pnas.0801389105;
RA Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T.,
RA Sakaki Y., Toyoda A., Hattori M., Ohkuma M.;
RT "Complete genome of the uncultured termite group 1 bacteria in a single
RT host protist cell.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008).
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR EMBL; AP009510; BAG13667.1; -; Genomic_DNA.
DR RefSeq; WP_015423195.1; NC_020419.1.
DR RefSeq; YP_001956128.1; NC_020419.1.
DR AlphaFoldDB; B1GZI5; -.
DR SMR; B1GZI5; -.
DR STRING; 471821.TGRD_184; -.
DR PRIDE; B1GZI5; -.
DR EnsemblBacteria; BAG13667; BAG13667; TGRD_184.
DR KEGG; rsd:TGRD_184; -.
DR PATRIC; fig|471821.5.peg.272; -.
DR HOGENOM; CLU_036856_0_1_0; -.
DR OMA; ISDHRVG; -.
DR OrthoDB; 928964at2; -.
DR Proteomes; UP000001691; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00019; prfA; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis.
FT CHAIN 1..356
FT /note="Peptide chain release factor 1"
FT /id="PRO_1000093520"
FT MOD_RES 233
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ SEQUENCE 356 AA; 40866 MW; AE2593933844457F CRC64;
MFLEKLKLLN SIFEEVESKL SDLSVISNQE EYRELTKQHF YLRPLAEKYI RYSKLLNEIK
DAEELQKSKD AEMKEIAFAE YNNLIEKRNQ MENEIKVLLI PTDPNEDKNI IVEIRAGTGG
NEAALFVGDL YGMYTRFAER NGWKYEVLGS NPTGLGGYKE VVFEINGGKV WRCFKFERGA
HRVQRVPETE ASGRVHTSAA TVAVLPEAEE VDVEIKMEDL RIDTYRASGA GGQHINKTDS
AIRITHLPTG LVVACQDERS QIKNRAKAFK VLRAKIYEQR ILEHEMRLSS ERKQQIGSGD
RSEKIRTYNF PQNRITDHRI GYSVYNITEV MDGNLSELVN KLIKADIESK LKENNI