RF1_FRACC
ID RF1_FRACC Reviewed; 357 AA.
AC Q2J6M0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093};
GN OrderedLocusNames=Francci3_3720;
OS Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3).
OC Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=106370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45818 / CECT 9043 / CcI3;
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR EMBL; CP000249; ABD13072.1; -; Genomic_DNA.
DR RefSeq; WP_011438096.1; NZ_LRTJ01000048.1.
DR AlphaFoldDB; Q2J6M0; -.
DR SMR; Q2J6M0; -.
DR STRING; 106370.Francci3_3720; -.
DR PRIDE; Q2J6M0; -.
DR EnsemblBacteria; ABD13072; ABD13072; Francci3_3720.
DR KEGG; fra:Francci3_3720; -.
DR eggNOG; COG0216; Bacteria.
DR HOGENOM; CLU_036856_0_1_11; -.
DR OMA; ISDHRVG; -.
DR OrthoDB; 928964at2; -.
DR PhylomeDB; Q2J6M0; -.
DR Proteomes; UP000001937; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00019; prfA; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT CHAIN 1..357
FT /note="Peptide chain release factor 1"
FT /id="PRO_0000263278"
FT MOD_RES 234
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ SEQUENCE 357 AA; 38701 MW; 6D2B0ECD24BDAE4B CRC64;
MTSPLDGLIA EHAEIEGQLA DPAVHNDPAK ARALSRRYAQ LAPVVDLARE LDRVEGDLAA
ARELALLDPS FRDEVQDLGE ELARLNDRLR AYLVPIDPDD ARDAILEVKA GAGGEESALF
AGDLLRMYLR YAERRGWKTE ILDANPSDLG GYRDVSVAVK ARGPAGPGDG VYGRLRFEGG
VHRVQRVPVT ESAGRIHTSA AGVLVLPEAE EVDVEIDPND LRIDVFRSSG PGGQSVNTTD
SAVRITHIPT GVVVSCQNEK SQLQNKESAL RILRARLLGA AREKAESEAS LARASQVRTV
DRSERVRTYN FAENRISDHR VGYKAHNLDQ VLDGELDEVL DALAAADLDA RLAAQAS
