RF1_FUSNN
ID RF1_FUSNN Reviewed; 365 AA.
AC Q8R5W0;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=FN1332;
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX NCBI_TaxID=190304;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC 2640 / LMG 13131 / VPI 4355;
RX PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR EMBL; AE009951; AAL95528.1; -; Genomic_DNA.
DR RefSeq; NP_604229.1; NC_003454.1.
DR AlphaFoldDB; Q8R5W0; -.
DR SMR; Q8R5W0; -.
DR STRING; 190304.FN1332; -.
DR EnsemblBacteria; AAL95528; AAL95528; FN1332.
DR KEGG; fnu:FN1332; -.
DR PATRIC; fig|190304.8.peg.1896; -.
DR eggNOG; COG0216; Bacteria.
DR HOGENOM; CLU_036856_0_1_0; -.
DR InParanoid; Q8R5W0; -.
DR OMA; ISDHRVG; -.
DR BioCyc; FNUC190304:G1FZS-1907-MON; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00019; prfA; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT CHAIN 1..365
FT /note="Peptide chain release factor 1"
FT /id="PRO_0000177674"
FT MOD_RES 242
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ SEQUENCE 365 AA; 41864 MW; 421003C10A4998AB CRC64;
MINLRGVKMF DKLEEVVARY DELNKMLVSP EVLADSKKMI ECNKAINEIT EIVEKYKEYK
KYVDDIEFIK ESFKTEKDSD MKEMLNEELK EAEEKLPKLE EELKILLLPK DKNDDKNVIV
EIRGGAGGDE AALFAADLFR MYSRYAERKK WKIEIIEKQD GELNGLKEIA FTIIGLGAYS
RLKFESGVHR VQRVPKTEAS GRIHTSTATV AVLPEVEDIQ EVTVDPKDLK IDTYRSGGAG
GQHVNMTDSA VRITHLPTGI VVQCQDERSQ LKNREKAMKH LLTKLYEMEQ EKQRSEVESE
RRLQVGTGDR AEKIRTYNFP DGRITDHRIK LTVHQLEAFL DGDIDEMIDA LITFHQAELL
SASEQ
