RF1_GRAFK
ID RF1_GRAFK Reviewed; 358 AA.
AC A0LYL5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=GFO_0477;
OS Gramella forsetii (strain KT0803).
OC Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Gramella.
OX NCBI_TaxID=411154;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT0803;
RX PubMed=17107561; DOI=10.1111/j.1462-2920.2006.01152.x;
RA Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E.,
RA Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K.,
RA Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I.,
RA Gloeckner F.O.;
RT "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii'
RT reveals adaptations to degradation of polymeric organic matter.";
RL Environ. Microbiol. 8:2201-2213(2006).
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR EMBL; CU207366; CAL65460.1; -; Genomic_DNA.
DR RefSeq; WP_011708398.1; NC_008571.1.
DR AlphaFoldDB; A0LYL5; -.
DR SMR; A0LYL5; -.
DR STRING; 411154.GFO_0477; -.
DR EnsemblBacteria; CAL65460; CAL65460; GFO_0477.
DR KEGG; gfo:GFO_0477; -.
DR eggNOG; COG0216; Bacteria.
DR HOGENOM; CLU_036856_0_1_10; -.
DR OMA; ISDHRVG; -.
DR OrthoDB; 928964at2; -.
DR Proteomes; UP000000755; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00019; prfA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis.
FT CHAIN 1..358
FT /note="Peptide chain release factor 1"
FT /id="PRO_1000004895"
FT MOD_RES 233
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ SEQUENCE 358 AA; 40698 MW; 03F8062AAAADBD1C CRC64;
MIERLNIVKQ RFDEVNDLII QPDVISDQKR YIELNKEYKD LRALMDEREK YISITDNIQE
AEEIISDGSD PEMTEMAKLQ LDEAKGQLPA LEDKIRMMLI PKDPEDGKNI VMEIRAGTGG
DEASIFAGDL YRMYTKYVEG RGWSHNIVDF SEGTSGGFKE MIFEVSGDDV YGTMKFEAGV
HRVQRVPQTE TQGRVHTSAA TVMVLPEAEE FDVEIDPKEV RIDYFCSSGP GGQSVNTTYS
AVRLTHEPTG LVAQCQDQKS QHKNKEKAFR VLRSRLYEME LAKKMEADAA KRNSMVSSGD
RSAKIRTYNY AQSRVTDHRI NLTLYDLSNI INGDIQKIID ELQLAENTEK LKENSDTI