ID   RF1_HALSA               Reviewed;         416 AA.
AC   Q9HNF0;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Peptide chain release factor subunit 1;
DE   AltName: Full=Translation termination factor aRF1;
GN   Name=prf1; OrderedLocusNames=VNG_2131G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG20270.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004437; AAG20270.1; ALT_INIT; Genomic_DNA.
DR   PIR; B84363; B84363.
DR   RefSeq; WP_012289438.1; NC_002607.1.
DR   AlphaFoldDB; Q9HNF0; -.
DR   SMR; Q9HNF0; -.
DR   STRING; 64091.VNG_2131G; -.
DR   PaxDb; Q9HNF0; -.
DR   EnsemblBacteria; AAG20270; AAG20270; VNG_2131G.
DR   GeneID; 5954067; -.
DR   GeneID; 62885298; -.
DR   KEGG; hal:VNG_2131G; -.
DR   PATRIC; fig|64091.14.peg.1629; -.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   InParanoid; Q9HNF0; -.
DR   OrthoDB; 32191at2157; -.
DR   PhylomeDB; Q9HNF0; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IBA:GO_Central.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..416
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_0000143171"
SQ   SEQUENCE   416 AA;  46638 MW;  DB239CB58F4ABE89 CRC64;
     MSEQDEVPSE DRRKYEFRKV IEELKDYEGS GTQLVTIYIP PDKQISDVVA HVTQEHSEAS
     NIKSKQTRTN VQDALTSIKD RLRYYDTFPP DNGMVVFSGA VDSGGGRTDM VTEVLESPPQ
     PIESFRYHCD SAFLTEPLAE MLGDKGLYGL IVLDRRESNV GWLKGKRVQP VKSAESLVPG
     KQRKGGQSAQ RFARLRLEAI DNFYQEVAGM ADDLFVPKRH EIDGILVGGP SPTKDEFLDG
     DYLHHELQDK VLGKFDVSYT DESGLSDLVD AGQAALAEAD LMDDKSDMEE FFEELNGGKL
     ATYGFEQTRR NLIMGSVDRL LVSEDLREDV VIYECPNDHE EYETIDRRNT SPEHTCSDCG
     EEATEVDRED AIDHLMSIAD QRGTETHFIS TDFEKGEQLL TAFGGYAGIL RYSTGV