AAGAB_MOUSE
ID AAGAB_MOUSE Reviewed; 316 AA.
AC Q8R2R3; Q3TW04; Q9CV78;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Alpha- and gamma-adaptin-binding protein p34;
GN Name=Aagab;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-312, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in endocytic recycling of growth factor
CC receptors such as EGFR. {ECO:0000250}.
CC -!- SUBUNIT: Associated with AP-1 and AP-2 complexes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
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DR EMBL; AK159897; BAE35463.1; -; mRNA.
DR EMBL; AK009203; BAB26137.1; -; mRNA.
DR EMBL; CH466522; EDL26044.1; -; Genomic_DNA.
DR EMBL; BC027311; AAH27311.1; -; mRNA.
DR CCDS; CCDS23271.1; -.
DR RefSeq; NP_080133.1; NM_025857.2.
DR AlphaFoldDB; Q8R2R3; -.
DR SMR; Q8R2R3; -.
DR BioGRID; 211824; 1.
DR STRING; 10090.ENSMUSP00000048595; -.
DR iPTMnet; Q8R2R3; -.
DR PhosphoSitePlus; Q8R2R3; -.
DR EPD; Q8R2R3; -.
DR jPOST; Q8R2R3; -.
DR MaxQB; Q8R2R3; -.
DR PaxDb; Q8R2R3; -.
DR PeptideAtlas; Q8R2R3; -.
DR PRIDE; Q8R2R3; -.
DR ProteomicsDB; 296463; -.
DR Antibodypedia; 26235; 119 antibodies from 22 providers.
DR Ensembl; ENSMUST00000041551; ENSMUSP00000048595; ENSMUSG00000037257.
DR GeneID; 66939; -.
DR KEGG; mmu:66939; -.
DR UCSC; uc009qbf.1; mouse.
DR CTD; 79719; -.
DR MGI; MGI:1914189; Aagab.
DR VEuPathDB; HostDB:ENSMUSG00000037257; -.
DR eggNOG; KOG4273; Eukaryota.
DR GeneTree; ENSGT00390000007218; -.
DR HOGENOM; CLU_056826_0_0_1; -.
DR InParanoid; Q8R2R3; -.
DR OMA; VTAFWKA; -.
DR OrthoDB; 1618204at2759; -.
DR PhylomeDB; Q8R2R3; -.
DR TreeFam; TF328856; -.
DR BioGRID-ORCS; 66939; 14 hits in 72 CRISPR screens.
DR ChiTaRS; Aagab; mouse.
DR PRO; PR:Q8R2R3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8R2R3; protein.
DR Bgee; ENSMUSG00000037257; Expressed in dorsal pancreas and 247 other tissues.
DR ExpressionAtlas; Q8R2R3; baseline and differential.
DR Genevisible; Q8R2R3; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019341; Alpha/Gamma-adaptin-bd_p34.
DR PANTHER; PTHR14659; PTHR14659; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..316
FT /note="Alpha- and gamma-adaptin-binding protein p34"
FT /id="PRO_0000058135"
FT REGION 198..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 312
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 151
FT /note="D -> N (in Ref. 3; AAH27311)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 34511 MW; F9AA6274ECAD8C21 CRC64;
MAAGVPCALV TSCSATFTGD RLVQHILGTE DAVVEATSSD AVRFYPWTID NKYYSAEINL
CVVPSKFLVT AEIAESVQAF VVYFDSTQKS GLDSVSSWLP LAEAWLAEVM ILVCDRVCDD
GINRQQAQEW CIKHGFELVE LNPEELPEED DDFPESTGVK RIVQALNANV WSNVVMKSDR
SQGFSLLNSL AGANRRVASA ESCHSEQQEP SPTAERTESL PGHHSGACGS AGAQVDSIVD
PMLDLDIQEL ASLTTGGGDL ENFERLFSKL KEMKDKAATL PHEQRKLHAE KVAKAFWMAI
GGDRDEIEGL SSDDEH
