RF1_LEGPL
ID RF1_LEGPL Reviewed; 362 AA.
AC Q5WUB1;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093}; OrderedLocusNames=lpl2257;
OS Legionella pneumophila (strain Lens).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=297245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lens;
RX PubMed=15467720; DOI=10.1038/ng1447;
RA Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA Glaser P., Buchrieser C.;
RT "Evidence in the Legionella pneumophila genome for exploitation of host
RT cell functions and high genome plasticity.";
RL Nat. Genet. 36:1165-1173(2004).
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR EMBL; CR628337; CAH16497.1; -; Genomic_DNA.
DR RefSeq; WP_010948042.1; NC_006369.1.
DR AlphaFoldDB; Q5WUB1; -.
DR SMR; Q5WUB1; -.
DR EnsemblBacteria; CAH16497; CAH16497; lpl2257.
DR GeneID; 66491463; -.
DR KEGG; lpf:lpl2257; -.
DR LegioList; lpl2257; -.
DR HOGENOM; CLU_036856_0_1_6; -.
DR OMA; ISDHRVG; -.
DR Proteomes; UP000002517; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; SSF75620; 1.
DR TIGRFAMs; TIGR00019; prfA; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methylation; Protein biosynthesis.
FT CHAIN 1..362
FT /note="Peptide chain release factor 1"
FT /id="PRO_0000177689"
FT MOD_RES 237
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ SEQUENCE 362 AA; 41103 MW; 6458FA460D5A015B CRC64;
MKKSLELKLQ QMLERYEEVG RLLSEASIIA DQNQFKSLSK EYAQLEPVSQ CYESYLEAKN
NLDSLNELLE SDDKDLATMA EEEIDTVKKQ IEELDEQLQW HLIPKDPDDE RNIYLEVRAG
TGGDEAAIFA GDLFRMYSRY AESQGWQIEL ISASHGEHGG YKEIIAKISG QAVYSQLKFE
SGAHRVQRVP ETESQGRVHT SACTVAIMPE VDEINDIQIN PDDLRIDTYR SSGAGGQHVN
KTDSAIRITH IPTGVVVECQ DERSQHKNRA KAMSLLKTRL LDAEVSKQKQ EQAQTRKSLV
GTGDRSERIR TYNFPQGRLT DHRINLTIYQ LSDIMEGNLS LVIDPLKREY HAELLADLGR
HD