ID   RF1_METJA               Reviewed;         421 AA.
AC   Q58239;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Peptide chain release factor subunit 1;
DE   AltName: Full=Translation termination factor aRF1;
GN   Name=prf1; OrderedLocusNames=MJ0829;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   FUNCTION.
RX   PubMed=10788613; DOI=10.1016/s0014-5793(00)01466-6;
RA   Dontsova M., Frolova L., Vassilieva J., Piendl W., Kisselev L., Garber M.;
RT   "Translation termination factor aRF1 from the archaeon Methanococcus
RT   jannaschii is active with eukaryotic ribosomes.";
RL   FEBS Lett. 472:213-216(2000).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000269|PubMed:10788613}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB98828.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L77117; AAB98828.1; ALT_INIT; Genomic_DNA.
DR   PIR; E64403; E64403.
DR   AlphaFoldDB; Q58239; -.
DR   SMR; Q58239; -.
DR   STRING; 243232.MJ_0829; -.
DR   EnsemblBacteria; AAB98828; AAB98828; MJ_0829.
DR   KEGG; mja:MJ_0829; -.
DR   eggNOG; arCOG01742; Archaea.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   InParanoid; Q58239; -.
DR   OMA; GQEMEVV; -.
DR   PhylomeDB; Q58239; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IBA:GO_Central.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..421
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_0000143174"
SQ   SEQUENCE   421 AA;  47508 MW;  6F3C642D466A8D5B CRC64;
     MASTDSKQLY LFKKMLKELK SKKGKGTELI SLYIPAGRRI SDVAQHLREE MSQASNIKSK
     STRKNVQSAI EAILQRLKLL KEPLEKGVVI FAGMVPRSGP GTEKMETYVI EPPEPIKTYI
     YRCDSEFYLE PLEEFLEDKD AYGVILVDRN EATIALVKGR NINILKKLTS GVPGKFKAGG
     QSARRLERLI DLAAHEFLQR VGQKANEQFL PLLQEKKLRG ILVGGPGHTK NEFVEGDYLH
     HELKKIVLDT FDLCYTEEFG IRELLEKAAP LLKDVELMKE REAVQRFLKE LIKEDGGLAC
     YGEKEVLEAL MMGAVDTLIV SEELEKYKVK IACNNCDYLE EKTVNKLELI KLEEELKNAQ
     CPKCGGALSI VEEKDYIEYL SELCEQSGAK LVTVSSETEE GAMILNAFKG IAAILRYKIH
     Q