ID   RF1_MYCPN               Reviewed;         359 AA.
AC   P75420;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Peptide chain release factor 1;
DE            Short=RF-1;
GN   Name=prfA; OrderedLocusNames=MPN_361; ORFNames=MP475;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000305}.
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DR   EMBL; U00089; AAB96123.1; -; Genomic_DNA.
DR   PIR; S73801; S73801.
DR   RefSeq; NP_110049.1; NC_000912.1.
DR   RefSeq; WP_010874717.1; NC_000912.1.
DR   AlphaFoldDB; P75420; -.
DR   SMR; P75420; -.
DR   IntAct; P75420; 3.
DR   STRING; 272634.MPN_361; -.
DR   EnsemblBacteria; AAB96123; AAB96123; MPN_361.
DR   KEGG; mpn:MPN_361; -.
DR   PATRIC; fig|272634.6.peg.388; -.
DR   HOGENOM; CLU_036856_0_1_14; -.
DR   OMA; ISDHRVG; -.
DR   BioCyc; MPNE272634:G1GJ3-568-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..359
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_0000177709"
FT   MOD_RES         236
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   359 AA;  40812 MW;  DAA730666E97A6A5 CRC64;
     MEFDKQFFSS VEKIVELAEQ LEKDLNKPDL TFEQIKAINK ELKHKQPLVV KFKEFKRLID
     QALEAEAILE NNELKELHDE AKKELERVRS VVPEYEEALK LLLLPIDENN QKNVIVELRP
     AAGGDESCIF LADLFNMYRN FCSNKGWKLQ INEMIPSSVG LNFVSFEVNG VDVFAKLKFE
     SGVHRVQRVP ATESKGRVHT STVTVAVLPQ LEAVEVHINP ADLRVDTYRA SGAGGQHVNR
     TESAVRITHL PTGIVVSCQE GKSQFTNRDT AMKMLRAKLW EKAQNEQLST QAGLRKSQVG
     SGDRAEKIRT YNYPQNRVTD HRIKLTVNKL NTIILGDLDE IIEALQADEK KQQLENFFS