ID   RF1_MYXXA               Reviewed;         362 AA.
AC   Q93NC7;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093};
OS   Myxococcus xanthus.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=34;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DZF1;
RA   Nariya H., Inouye S.;
RT   "Identification of serine/threonine kinase associate proteins in M. xanthus
RT   by yeast two-hybrid system.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF377339; AAK64443.1; -; Genomic_DNA.
DR   RefSeq; WP_011554888.1; NZ_JABFNQ010000126.1.
DR   AlphaFoldDB; Q93NC7; -.
DR   SMR; Q93NC7; -.
DR   GeneID; 41362195; -.
DR   OMA; ISDHRVG; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis.
FT   CHAIN           1..362
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_0000177712"
FT   MOD_RES         232
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   362 AA;  40142 MW;  60689756C54C07E9 CRC64;
     MIDKLEDVER RFERLTADLS NPDVLADSAR LQKVSKERAG LEKLVEAFRT YRKVLADLSE
     VEAWLGSSDA DEKAFARESL PGLKEQRDEL EASLKILLLP KDPNDEKNVI LEIRAGAGGD
     EAALFAEEVM QMYLRYADRR GWKADILDMS PGNAGGVKDA TVTLSGDAVF SSMKYESGVH
     RVQRVPATET QGRIHTSTIT VSVMPEAEDV DVQVNPADIE MQVMRSTGSG GQSVNTTDSA
     VRLIHHPTGI VVKCQQEKSQ LKNRTMAMRM LRAKLYDIEQ ERIRNERDSA RRAQVGTGDR
     SEKIRTYNFP QDRLTDHRIG LTVHNLPGVM AGDVEDVITA CRTFYQAEAL KAQTAGGPKP
     SA