ID   RF1_PYRAB               Reviewed;         414 AA.
AC   Q9V151; G8ZJ43;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Peptide chain release factor subunit 1;
DE   AltName: Full=Translation termination factor aRF1;
GN   Name=prf1; OrderedLocusNames=PYRAB05780; ORFNames=PAB0396;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB49500.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ248284; CAB49500.1; ALT_INIT; Genomic_DNA.
DR   EMBL; HE613800; CCE69970.1; -; Genomic_DNA.
DR   PIR; E75177; E75177.
DR   RefSeq; WP_048146580.1; NC_000868.1.
DR   AlphaFoldDB; Q9V151; -.
DR   SMR; Q9V151; -.
DR   STRING; 272844.PAB0396; -.
DR   PRIDE; Q9V151; -.
DR   EnsemblBacteria; CAB49500; CAB49500; PAB0396.
DR   GeneID; 1495483; -.
DR   KEGG; pab:PAB0396; -.
DR   PATRIC; fig|272844.11.peg.616; -.
DR   eggNOG; arCOG01742; Archaea.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   OrthoDB; 32191at2157; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Protein biosynthesis.
FT   CHAIN           1..414
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_0000143180"
SQ   SEQUENCE   414 AA;  47376 MW;  4DCD6DDF9F6E04E3 CRC64;
     MTRHDAQLYE LKKKIEELKK IRGRGTELIS LYIPAGYDLS KVMQQLREEY STAQNIKSKT
     TRKNVLGALE RAMQHLKLYK QTPENGLALF VGNVSEMEGN TDIRLWAIVP PEPLNVRLYR
     CDQTFVTEPL EEMLRVKDAY GLITVEKNEA TIGLLRGKRI EVLDELTSNV PGKTRAGGQS
     ARRYERIREQ ETHEFMKRIG EHANRVFLPL LEKGELKGII VGGPGPTKED FVEGDYLHHE
     LKKKIIGVVD ISYHGEYGLR ELVEKASDIL RDHEVIREKK LVNEFLKHVV KDTGLATYGE
     REVRRALEIG AVDTLLISEG YDKVRVRAKC NHCGWEELKT MSEEEFEVYK KKLTRCPKCG
     SQNLTIEKWD VAEELIKMAE EAGSDVEIIS LDTEEGQQFY RAFGGLGAIL RFKI