ID   RF1_SACS2               Reviewed;         369 AA.
AC   Q97W96;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Peptide chain release factor subunit 1;
DE   AltName: Full=Translation termination factor aRF1;
GN   Name=prf1; OrderedLocusNames=SSO2339;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: Directs the termination of nascent peptide synthesis
CC       (translation) in response to the termination codons UAA, UAG and UGA.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of two subunits, one of which binds GTP.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q97W96; Q980K5: SSO0287; NbExp=2; IntAct=EBI-15910165, EBI-15910144;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK42492.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE006641; AAK42492.1; ALT_FRAME; Genomic_DNA.
DR   PIR; E90404; E90404.
DR   DIP; DIP-60311N; -.
DR   IntAct; Q97W96; 1.
DR   STRING; 273057.SSO2339; -.
DR   EnsemblBacteria; AAK42492; AAK42492; SSO2339.
DR   KEGG; sso:SSO2339; -.
DR   PATRIC; fig|273057.12.peg.2425; -.
DR   eggNOG; arCOG01742; Archaea.
DR   HOGENOM; CLU_035759_3_0_2; -.
DR   InParanoid; Q97W96; -.
DR   OMA; GQEMEVV; -.
DR   PhylomeDB; Q97W96; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0018444; C:translation release factor complex; IBA:GO_Central.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IBA:GO_Central.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.30.420.60; -; 1.
DR   Gene3D; 3.30.960.10; -; 1.
DR   HAMAP; MF_00424; Rel_fact_arch_1; 1.
DR   InterPro; IPR042226; eFR1_2_sf.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR024049; eRF1_1_sf.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR020918; Peptide_chain-rel_aRF1.
DR   InterPro; IPR004403; Peptide_chain-rel_eRF1/aRF1.
DR   PANTHER; PTHR10113; PTHR10113; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF55481; SSF55481; 1.
DR   TIGRFAMs; TIGR03676; aRF1/eRF1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..369
FT                   /note="Peptide chain release factor subunit 1"
FT                   /id="PRO_0000143185"
SQ   SEQUENCE   369 AA;  42310 MW;  EFE1726D2E97000F CRC64;
     MSXDEYALNK QELKALIKEL KKWKAPATVL LSLYIPPGRP IPDVVNLLRQ EYSIAQNIKL
     KRTRDAVLSA IGAAIDRLNK IPKIDGNGLV LFCGENFDTE DFKCFMFSPP DKVPLFFYRT
     DKEFHLEFLE DMVEDTAVYG LIIVERDEAT IGLLKGARIE ILEEIEGFVP GKHMMGGQSQ
     RRIDRIIDEM YHNFLKEVGE KVNAYFMPFV QNGKMKGVLL GGPGYAKEDF YKEDYVDYRI
     KNLILQPLID VSDQGEVGLR EMIMKAEDLL KNQQYIEVEK LLEELKYHLA KDDGLIIYGK
     EQIKKAMEIG AIEAIVIHED STDKELEKLA QDAENYGVKV FVVGDEVPEA EWVKKTFNGI
     VGKLRYRLY