ID   RF1_SYNPW               Reviewed;         365 AA.
AC   A5GIR6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Peptide chain release factor 1 {ECO:0000255|HAMAP-Rule:MF_00093};
DE            Short=RF-1 {ECO:0000255|HAMAP-Rule:MF_00093};
GN   Name=prfA {ECO:0000255|HAMAP-Rule:MF_00093};
GN   OrderedLocusNames=SynWH7803_0405;
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=32051;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH7803;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC       translation in response to the peptide chain termination codons UAG and
CC       UAA. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- PTM: Methylated by PrmC. Methylation increases the termination
CC       efficiency of RF1. {ECO:0000255|HAMAP-Rule:MF_00093}.
CC   -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC       family. {ECO:0000255|HAMAP-Rule:MF_00093}.
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DR   EMBL; CT971583; CAK22831.1; -; Genomic_DNA.
DR   RefSeq; WP_011932327.1; NC_009481.1.
DR   AlphaFoldDB; A5GIR6; -.
DR   SMR; A5GIR6; -.
DR   STRING; 32051.SynWH7803_0405; -.
DR   EnsemblBacteria; CAK22831; CAK22831; SynWH7803_0405.
DR   KEGG; syx:SynWH7803_0405; -.
DR   eggNOG; COG0216; Bacteria.
DR   HOGENOM; CLU_036856_0_1_3; -.
DR   OMA; ISDHRVG; -.
DR   OrthoDB; 928964at2; -.
DR   Proteomes; UP000001566; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00093; Rel_fac_1; 1.
DR   InterPro; IPR005139; PCRF.
DR   InterPro; IPR000352; Pep_chain_release_fac_I.
DR   InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR   InterPro; IPR004373; RF-1.
DR   Pfam; PF03462; PCRF; 1.
DR   Pfam; PF00472; RF-1; 1.
DR   SMART; SM00937; PCRF; 1.
DR   SUPFAM; SSF75620; SSF75620; 1.
DR   TIGRFAMs; TIGR00019; prfA; 1.
DR   PROSITE; PS00745; RF_PROK_I; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methylation; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Peptide chain release factor 1"
FT                   /id="PRO_1000004962"
FT   REGION          291..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         239
FT                   /note="N5-methylglutamine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00093"
SQ   SEQUENCE   365 AA;  40750 MW;  027B583BF9892E90 CRC64;
     MDPSTLISRL EAARSSFHNL ERQLADPDVA SDPTRLQSIA RERSRLEPLV NDYASLQAVQ
     SEREQARELL RDSRGDEEMA HLAQLELDEL DIRHEALIER LTLALLPRDP RDERSVMLEI
     RAGAGGDEAC LWAGDLARMY ERFSSRRGWT VQPVSASEAD LGGFKELILS VKGESVFSEL
     KFEAGVHRVQ RVPATESQGR VHTSTATVAV MPEADPVEVQ IEPADLEIST ARSGGAGGQN
     VNKVETAVDL MHRPSGIRVF CTQERSQLQN RERAMEILRA KLYERQLAEA NARESSARRA
     QVGTGDRSEK IRTYNAKDNR VTDHRLGRNF SLDPVLQGQM EDVIGACIAE EQRSKLEALS
     RQSDD